| Objective1.To objectively evaluate the clinical efficacy of Jiawei-baihu decotion in the treatment of Rosacea?Lung-stomach heat syndrome?,so as to provide support for the clinical application of this prescription;2.To preliminary discuss the correlation between Jiawei-baihu decotion and Helicobacter Pylori in the treatment of Rosacea?Lung-stomach heat syndrome?.MethodA total of 64 cases of patients with Rosacea?Lung-stomach heat syndrome?were randomly divided into the experimental group and the control group,32 cases in each group.Oral Jiawei-baihu decotion combined with external department's self-made Arnebia oil were used in the experimental group;Oral doxycycline combined with external department's self-made Arnebia oil were used in the control group.The treatment course was 4 weeks and the follow-up period was 6 weeks.The changes of symptom integral of patients before treatment and at the end of 4th week after treatment were observed to evaluate efficacy,and changes of symptom integral at the 6 weeks after drug withdrawal were observed to evaluate long-term efficacy.At the same time,the infection rate of Helicobacter Pylori in 64 patients was calculated to discuss the correlation between Helicobacter Pylori and Jiawei-baihu decotion in the treatment of Rosacea?Lung-stomach heat syndrome?.Result1.The comparative analysis of age,sex,Helicobacter Pylori infection,Rosacea classification,symptom scores and symptom integral between the treatment group and the control group before inclusion showed no statistical significance?P>0.05?.The data of the two groups were comparable.2.Comparison of various symptoms scores:Scores of symptoms of dryness,burn,pruritis,erythema and papules pustules in the two groups at the end of 4th week of treatment and the6th week after drug withdrawal all decreased compared with those before treatment?P<0.05?,and the scores of symptoms in the treatment group were all lower than those in the control group at the end of 4th week of treatment and the 6th week after drug withdrawal,with statistically significant difference.There was no difference between the two groups in the scores of capillary dilatation symptoms at the three time points of before treatment,the end of the 4th week of treatment and the 6th week after drug withdrawal?P>0.05?,and the symptoms of capillary dilatation were not effectively improved.3.Comparison of symptom integral:At the end of the 4th week,the average symptom score in the experimental group was 4.50±2.02 points and that in the control group was6.22±2.21 points,and the difference in the symptom integral was statistically significant?P<0.05?;At the 6th week after drug withdraw,the average symptom score in the experimental group was 4.72±2.11 points and that in the control group was 6.88±2.34 points,and the difference in the symptom integral was statistically significant?P<0.05?.4.Comparison of treatment efficiency and recurrence rate:The effective rate of treatment at the end of the 4th week in the treatment group was 84.40%,higher than that in the control group?62.50%?,and the difference in efficacy between the two groups was statistically significant?P<0.05?.The effective rate of treatment at the 6th week after drug withdraw in the treatment group was 68.75%,higher than that in the control group?34.37%?,and the difference in efficacy between the two groups was statistically significant?P<0.05?.At the 6th week after drug withdrawal,there were 5 recurrent cases in the treatment group,with a recurrence rate of 18.51%,and there were 9 recurrent cases in the control group,with a recurrence rate of 45.00%.The difference of recurrence rate between the two groups was statistically significant?P<0.05?.5.Helicobacter Pylori infection:The infection rate of Helicobacter Pylori in 64 patients with Rosacea?Lung-stomach heat syndrome?was 62.50%,which was significantly different from 31.54%in healthy people in Fuzhou area[1].In the experimental group,the infection rate of Helicobacter Pylori was 68.80%before treatment,and 21.90%at the 6th week after drug withdraw,showing statistical difference between the two time points?P<0.05?.In the control group,the infection rate of Helicobacter Pylori was 56.30%before treatment,and 50.00%at the 6th week after drug withdraw,showing no statistical difference between before treatment and at the 6th week after drug withdraw?P>0.05?.Conclusion1.Jiawei-baihu decotion and doxycycline were both effective in improving dryness,burn,pruritis,erythema and papules pustules of Rosacea?Lung-stomach heat syndrome?.The therapeutic effect of Jiawei-baihu decotion was better than that of doxycycline,and the long-term recurrence rate was lower,which is worthy of clinical research and promotion.2.Jiawei-baihu decotion had certain inhibitory effect on Helicobacter Pylori,whose infection rate in patients with Rosacea?Lung-stomach heat syndrome?was high. |
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