Observation On Therapeutic Effect Of Majingzhike Granules On Post-Infectious Cough With Wind Invading Lung-Type

Objective:To observe the therapeutic effect of majingzhike granules in the treatment of post-infectious cough patients with wind invading lung-type and provide a reliable basis for traditional chinese medicine in the treatment of PIC.Methods:This study collected into standard wind invading lung-type in patient with PIC(72 cases),adopt the single blind random control method,divided into teeatment group(n=36)and control group(n=36).The treatment group take majingzhike granules,and the control group take the compound methoxyphenamine capsules(Asmeton).The period of treatment is two weeks.To observe the change of cough visual analogue scale,leicester cough questionnaire,sputum index before and after treatment for two weeks and TCM syndrome integral and cough score intreatment for before?after one week and after two weeks.SPSS 23.0 statistical software was used for data sorting and analysis.Results: sputum,1.TCM syndrome score:Intra-group comparisons: After one week and two weeks 'treatment,the score of symptoms of cough and pharyngeal itching were lower than before treatment in the treatment group and control group(P<0.05).The score of symptom of sputum was lower than before treatment in the treatment group(P<0.05)and was no significant difference before and after treatment in the control group(P>0.05).Between the groups:The decreased symptoms of sputum score in the treatment group was significantly higher than that in the control group(P<0.05).The improvement degree of symptoms of cough and pharyngeal itching score in the group and the control group was similar after one week and two weeks of treatment(P>0.05).2.Cough visual analogue scale:After two weeks of treatment,cough visual analogue scale score in the treatment group and the control group were lower than before(P<0.05).The improvement degree of cough visual analogue scale score in the treatment group and the control group were similar after treatment(P>0.05).3.Chinese version of LCQ questionnaire:after two weeks of treatment,the LCQ score of the treatment group and the control group were higher than before(P<0.05).After treatment,the LCQ score of the treatment increased more than that of the control group(P<0.05).4.Sputum inflammatory mediators:After two weeks of treatment,sputum SP and IL-8 levels in the treatment group and the control group were lower than before(P<0.05).After treatment,sputum SP and IL-8 levels in the treatment group and the control group were similar(P>0.05).5.Comparison of TCM syndrome effect: After one week of treatment,the effective rate of TCM syndrome points was 88.24% in the treatment group and 78.79% in the control group.Compared to the difference was similar(P>0.05).After two weeks of treatment,the effective rate of TCM syndrome points was 91.18% in the treatment group and 84.85% in the control group.Compared to the difference was statistically significant(P<0.01).6.Comparison of clinical efficacy: After two weeks of treatment,insignificant efficiency was 91.18% in the treatment group and 93.94% in the control group(P>0.05).Conclusions:1.Majingzhike granules has a significant curative effect on patients with wind invading lung-type post-infectious cough.2.Majingzhike granules have more obvious effects in terms of improvement of sputum and patients' living quality.3.Majingzhike granules can reduce the levels of sputum inflammatory mediators SP and IL-8.