Clinical Observation Of Jiawei Bufei Decoction In Treating The Syndrome Of Deficiency Of Lung And Kidney Qi And Stasis In The Stable Stage Of Chronic Obstructive Pulmonary Disease

Objective:The purpose of this study is to observe the changes of clinical symptoms,pulmonary function and quality of life of the patients with chronic obstructive pulmonary disease(COPD)in stable stage treated by Jiawei Bufei decoction,to evaluate the clinical efficacy of Jiawei Bufei Decoction in the treatment of COPD in stable stage,to explore the advantages of the combination of Chinese and Western medicine in the treatment of COPD,and to provide evidences for clinical treatment.Methods: 64 patients with lung-kidney Qi deficiency and blood stasis syndrome in stable stage of chronic obstructive pulmonary disease were selected strictly according to the inclusion and exclusion criteria of the study design.A randomized control design was adopted.SPSS22.0 statistical software was used to randomly divide them into treatment group and control group in a 1:1 ratio,with 32 cases in each group.Patients in the control group were given conventional western medicine treatment(tiotropium bromide powder inhalation(Sirihua)one inhalation per day(18ug/inhalation),while patients in the treatment group were given conventional western medicine treatment + modified Bufei Decoction(tiotropium bromide powder inhalation + modified Bufei decoction),and the course of treatment in both groups was 8 weeks.Observations and Analysis were rendered to the general conditions(gender,age,course of disease,smoking history)before and after treatment,and the changes of TCM syndrome score,improvement rate of syndrome score,lung function(FEV1/FVC%,FEV1% Pred),modified British Medical Research Council dyspnea score(m MRC),chronic obstructive pulmonary disease assessment questionnaire(CAT),six-minute walk test(6MWT)before and after treatment.Finally,the data collected in the experiment were sorted out and statistically analyzed using spass22.0 statistical software.Result:(1)Baseline data analysis of the two groups before the experiment: before the experiment,the baseline data of sex ratio,average age,course of disease,smoking history,lung function(FEV1/FVC%,FEV1% Pred),TCM syndrome score,m MRC score,CAT score,6MWT of the two groups were compared,and no significant difference was found(P<0.05),which suggests the comparability between the two groups.(2)Comparison of TCM syndrome scores between the two groups before and after treatment: the total score of TCM syndrome after treatment in both groups decreased significantly compared with that before treatment,and the difference was statistically significant(P < 0.05).There was a significant difference between the two groups in the total score of TCM syndromes after treatment(P < 0.05);there was a significant difference between the difference before and after treatment(P < 0.05).After treatment,the total effective rate was 96.67% in the treatment group and 83.33% in the control group,and the difference was statistically significant(P < 0.05).(3)Comparison of lung function(FEV1/FVC%,FEV1% Pred)between the two groups before and after treatment: FEV1/FVC% and FEV1% Pred in the two groups after treatment were improved compared with those before treatment,and the difference between the two groups after treatment and between the two groups before and after treatment was statistically significant(P < 0.05).The difference of FEV1/FVC% and FEV1% Pred between the two groups before and after treatment was statistically significant(P < 0.05).(4)Comparison of m MRC score and CAT score between the two groups before and after treatment: m MRC score and CAT score in both groups decreased after treatment compared with before treatment,and there was a significant difference between each group(P < 0.05).The difference of m MRC score and CAT score between the two groups before and after treatment was statistically significant(P < 0.05).(5)Comparison of 6MWT distance between the two groups before and after treatment: the 6MWT distance between the two groups after treatment was improved compared with that before treatment,and the difference was statistically significant(P < 0.05);the difference between groups was statistically significant(P < 0.05).The difference of 6MWT distance between the two groups before and after treatment was statistically significant(P < 0.05).Conclusion: Jiawei Bufei Decoction combined with conventional western medicine in the treatment of patients with stable chronic obstructive pulmonary diseases(lung and kidney qi deficiency with stasis syndrome)has more advantages than the simple western medicine group in alleviating patients’ clinical symptoms,improving patients’ pulmonary function,improving patients’ dyspnea,improving patients’ quality of life and activity tolerance,and has better clinical efficacy.