| Objective:To evaluate the osteogenic effect of concentrated growth factor（CGF）combined with deproteinized bovine bone mineral（DBBM）in site preservation by clinical and histomorphometric observation.Methods :A total of 28 patients needed extraction of affected teeth and received staged implantation after site preservation were selected.The patients were randomly divided into control group（Bio-Oss was implanted simultaneously after extraction）and experimental group（CGF+Bio-Oss was implanted simultaneously after extraction）,with 14 patients in each group,and both groups were covered with Bio-Gide collagen membrane.Cone beam computed tomography（CBCT）was taken between preoperative and 6 months postoperatively to measure the changes of alveolar bone height and width,and the bone specimens were drilled 6 months after site preservation during implant surgery for histological analyses.Results:CBCT showed that the height and width of alveolar bone were absorbed 6 months after site preservation in the experimental and control group,and the reduction of alveolar ridge width in the experimental group was statistically less than the control group（P<0.05）.The histomorphometry results showed that the percentage of new bone in the experimental and control group were 35.30±3.56% and 26.38±5.04% respectively,and the amount of new bone in the experimental group was statistically higher than the control group（P<0.05）.Conclusion:CGF combined with DBBM is superior to DBBM in maintaining the alveolar bone volume in site preservation,which creates favorable conditions for implant restoration. |
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