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A Randomized And Double-blind Clinical Trial Of Huanglong Zhike Capsule In The Treatment Of Chronic Cough(Wind Clonus Acute Type)

Posted on:2021-03-20Degree:MasterType:Thesis
Country:ChinaCandidate:X L YangFull Text:PDF
GTID:2404330614458954Subject:Integrated Chinese and Western medicine clinical
Abstract/Summary:PDF Full Text Request
Objective:The purpose of this study was to observe the efficacy and safety of Huanglong Zhike capsule in treating wind clonus acute type of chronic cough.Methods:In this study,170 patients with chronic cough who met the study standards were randomly divided into two groups,each group containing 85 patients.The control group was given Suhuang Zhike capsule orally,and the treatment group was given Huanglong Zhike capsule orally for two weeks.To observe the drug safety,visual analogue scale,cough symptom score,TCM symptom score and LCQ score before and after treatment were compared between the two groups.Results:1.According to statistical analysis,there was no significant difference in gender,age,cough symptom score,LCQ score and other data before treatment between the two groups(P>0.05),indicating comparability.2.VAS:There was a statistically significant difference in VAS between the two groups before and after treatment(P<0.05),and there was no significant difference in VAS between the two groups after treatment or between the two groups before and after treatment(P>0.05).3.Cough symptom score: There was a statistically significant difference in cough symptom score between the two groups before and after treatment(P<0.05),and there was no significant difference in cough symptom score between the two groups after treatment or between the two groups before and after treatment(P>0.05).4.TCM symptom score: The difference of TCM symptom score between the two groups before and after treatment was statistically significant(P<0.05),and there was no significant difference between the two groups after treatment and the difference of TCM symptom score between the two groups before and after treatment(P>0.05).5.LCQ score: There was a statistically significant difference in LCQ scores and total scores between the two groups before and after treatment(P<0.05),and there was no significant difference in LCQ score and total scores between the two groups after treatment(P>0.05).6.Efficacy of the two groups: In terms of integral efficacy of cough symptoms,the effective rate of the treatment group was 80.24%,and that of the control group was 80.29%,with no statistically significant difference(P>0.05).In terms of TCM syndrome efficacy,the effective rate in the treatment group was 81.48%,and that in the control group was 79.27%,with no statistically significant difference(P>0.05).7.Adverse reactions: Two patients in the treatment group showed mild epigastric discomfort,which disappeared spontaneously after one to three days.In the control group,one patient developed nausea and gastric discomfort,and the test was suspended.Constipation was observed in one case,which was improved after symptomatic treatment.Conclusion:Huanglong Zhike capsule can effectively improve the cough,cough sputum,pharyngeal itch,shortness of breath and other symptoms of wind clonus acute type of chronic cough patients and improve the quality of life of patients.It has high safety and its treatment of cough symptoms is not inferior to Suhuang Zhike capsule.
Keywords/Search Tags:chronic cough, wind clonus acute type, Huang Long Zhike capsule, clinical study
PDF Full Text Request
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