Clinical Observation On The Effect Of Gancao Xiexin Decoction In The Treatment Of Deficiency And Damp Heat Blocking Cancer-related Fatigue

Research purpose: This study is mainly to use Gancao Xiexin Decoction to treat patients with deficiency due to deficiency and dampness due to damp heat,and evaluate the improvement of fatigue,TCM symptoms,KPS score and quality of life in patients with fatigue due to dampness and dampness due to Qi deficiency.Situation,and the evaluation of drug safety at the same time,to provide more ideas and reference for the clinical treatment of the disease.Research subjects and methods: This study adopts a randomized controlled trial method.65 patients with cancer-related fatigue that meet the inclusion criteria will be collected from the inpatient department of the Oncology Department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(moderate deficiency,damp heat block type)They were randomly divided into a Chinese medicine group and a control group.The control group was only treated with Western medicine symptomatic basic treatment.The treatment group was treated with Gancao Xiexin Decoction for basic treatment.The intervention was conducted for 8weeks,with 4 weeks as a course of treatment.Questionnaires were collected and compared.The Piper fatigue scale score,quality of life test(EORTC QLQ-C30),TCM symptom score scale,and KPS score scale before and after intervention in the group were used to evaluate the deficiency of dampness and heat and dampness in the treatment of Gancao Xiexin Decoction.The efficacy of cancer due to fatigue is based on blood routine,urine routine,routine stool + occult blood test,liver function,kidney function,electrolytes,and electrocardiogram as indicators of safety observation to evaluate the safety of traditional Chinese medicine.Results: By the end of the study,there were a total of 5 cases of shedding in the two groups,3 cases in the treatment group,2 cases in the control group,and the remaining 60 cases were all valid cases.1.General data comparison: Demographic data showed that before treatment,no significant differences were found between the two groups in terms of age,gender,tumor stage,tumor diagnosis,and previous tumor-related treatments(P> 0.05).2.Gancao Xiexin Decoction can effectively improve the Piper fatigue scale points.It first showed a significant improvement in the patient's physical fatigue at 4weeks of treatment.At 8 weeks of treatment,it had behavioral fatigue,emotional fatigue,and physical fatigue.Significant improvement means better benefit when treatment time is extended to 8 weeks.3.The addition and subtraction of Gancao Xiexin Decoction can improve the functional score and symptom score of the quality of life scale.In terms of functional scores,social function scores were improved at 4 weeks of treatment,and physical function,social function,and emotional function were also improved at 8 weeks of treatment.Compared with 4 weeks of treatment,8 weeks of treatment significantly improved physical function scores.In terms of symptomatic scores,fatigue,shortness of breath,constipation,and diarrhea were improved at 4 weeks of treatment,and fatigue,constipation,and diarrhea were improved at 8 weeks.Especially when thetreatment time was extended to 8 weeks,fatigue and shortness of breath remained.Further improvement.4.Gancao Xiexin Decoction can significantly improve the TCM syndrome scores of patients with cancer-related fatigue,and the better the improvement over time,and the effective rate is more significant in the 8th week than in the 4th week..5.Gancao Xiexin Decoction can help improve the KPS score of patients.The treatment time is 4 weeks and 8 weeks,and the benefits are also improved at 8 weeks compared with 4 weeks.6.Safety evaluation: There were no significant differences in blood routine,urine routine,stool routine + routine blood + occult blood,liver function,renal function,electrolytes,electrocardiogram,etc.in the two groups before and after treatment(P > 0.05)Research conclusions: 1.Both Chinese and Western medicine treatments can improve fatigue and fatigue in patients with cancer-related fatigue due to damp-heat block,clinical manifestations of TCM syndromes,improve patient physical status,and improve patient quality of life.Reduced treatment has more significant effects.Western medicine treatment has a certain time limit.The longer the time of traditional Chinese medicine,the better the effect.2.The addition and subtraction of Gancao Xiexin Decoction not only has significant curative effect in clinical treatment,but also is safe,reliable,and no obvious side effects.It provides a new treatment approach for patients with cancer-related fatigue,and the patient compliance is good,which is worthy of clinical promotion use.