Effect Of Polymorphism On IL1A To Prostate Cancer And Tumor Susceptibility

Objective:To investigate the association of three SNPS of IL1 A gene rs17561,rs1800587 and rs37835553 with prostate cancer and cancer susceptibility.Methods: As of May 20,2019,comprehensive searches of relevant literatures were carried out from several online databases: Web of Science,Google Scholar,Pub Med,EMBASE,CNKI database,and Wanfang database.After rigorous screening,a total of 40 case-control studies were included,adding up to 15,586 for patients(case group),as well as 18,430 for healthy subjects(control group).STATA 12.0 was run to execute statistical calculations.We used odds ratios(ORs)with 95% confidence intervals(CIs)to demonstrate the computation result of each genic model in overall and stratified groups to appraise the correlation between IL1 A polymorphism and cancer susceptibility,and we also performed ?~2 test to checkout Hardy–Weinberg equilibrium(HWE)of control group.The Newcastle-Ottawa scale(NOS)was used to assess the quality of the overall study,the ?~2-based Q test was used to assess heterogeneity,and Begg's test and Egger's test were used to assess publication bias,and sensitivity analysis was performed.Results: IL1 A rs17561 polymorphism has no significant correlation with cancer susceptibility,either by overall analysis or by subgroup analysis of cancer type and ethnicity.In the analysis of IL1 A rs1800587 polymorphism,there was a statistically significant difference in overall risk between the allele comparison model and the homozygous comparison model and cancer susceptibility.The results of the subgroup analysis showed that the homozygous and recessive mutation models significantly increased the susceptibility to cervical cancer,and there was a significant correlation between the allele comparison model of population-based group and the recessive comparison model of hospital-based group and the high susceptibility to cancer.As for rs3783553,studies showed strongly significantly links with positive risk to prostate cancer and overall cancers in all genetic models.The subgroup analysis revealed that population-based subgroup analysis found a greatly increased risk in all five comparison models,and analysis using ethnicity as subgroup hinted a closely association,in both Asian and Caucasian,between mutation and high cancer susceptibility risk in all five models.Conclusion:1.There is a significant relationship between the insertion/deletion of SNP in IL1 A rs3783553 and the increased risk of overall cancer susceptibility,including prostate cancer.2.Mutations in the allele C>T and mutations in the homozygous model of IL1 A rs1800587 SNP may potentially increase the risk of cancer susceptibility to overall tumors,and mutations in the homozygous model and the recessive model significantly increase the susceptibility of cervical cancer.