Correlation Between Macrophage Migratio Ihhibitory Factor-173G/C Gene Polymorphism To The Risk Of Cancer In Chinese Population:a Meta-Analysis

Objective: Macrophage migration inhibitory factor(MIF)-173G/C gene polymorphism has been associated with cancer risk.Previous studies have revealed that MIF-173G/C gene polymorphism may increase cancer in the Chinese population,while results of individual published studies remain inconsistent and inconclusive.We performed this meta-analysis to derive a more precise estimation of the relationship.Methods: We conducted a search on Pub Med,Embase,MEDLINE,Cochrane Library,Chinese National Knowledge Infrastructure(CKNI),Wanfang,Weipu on July 20,2017.Odds ratio(OR)and 95% confidence interval(95%CI)were used to assess the association.A total of 8 studies including 2,186 cases and 2,285 controls were included in this meta-analysis.Result: The pooled results indicated the significant association between MIF-173G/C polymorphism and the risk of cancer for Chinese population(CC/CG+GG: OR=1.12,95%CI=1.02-1.23,P =0.017,p< 0.05;CC / GG: OR=1.18,95%CI=1.04-1.33,P=0.008?p < 0.05;CG / GG: OR=1.03,95%CI=0.91-1.15,P=0.042,p < 0.05;C / G: OR=1.24,95%CI=1.14-1.25,P =0.045,p <0.05).Subgroup analysis showed that in patients with “ solid tumors ”,(OR=0.94,95%CI=0.83-1.06,p=0.023,p<0.05).Within“non-solid tumors” the association become stronger(OR=6.62,95%CI=4.32-10.14,p=0.001,p<0.05).Conclusion: this study suggested that MIF-173G/C gene polymorphism may increase cancer risk in Chinese population.