The Clinical Observation Of Buxinruanmai Granule In The Treatment Of Stable Coronary Heart Diseasee Complicated With Carotid Atherosclerosis

Objective:By observing the clinical efficacy of buxinruanmai(BXRM)granule combined with conventional western medicine in the treatment of patients with stable coronary heart disease and carotid atherosclerosis and TCM syndromes are deficiency of both qi and Yin,phlegm and blood stasis.And evaluating the effect of buxinruanmai(BXRM)granule on carotid ultrasound,blood lipids,and its safety.Methods:66 patients were randomly divided into the treatment group and the control group,33cases in each group.Their diagnosis was with stable coronary heart disease and carotid atherosclerotic plaque and TCM syndromes are deficiency of both qi and Yin,phlegm and blood stasis.The treatment group was treated with buxinruanmai(BXRM)granule and Western medicine standardization,while the control group was treated with western medicine standardization.To observe the changes of carotid ultrasound results,blood lipid,heart ultrasound,liver and kidney function and TCM syndrome score before and after treatment,and to evaluate the clinical effect and safety of buxinruanmai(BXRM)granule on carotid atherosclerotic plaque of coronary heart disease.Results:TCM syndrome score:?DAfter treatment,the scores of TCM syndromes in the two groups were decreased,and there was a significant difference between the two groups(P<0.01).The scores in the treatment group were lower than those in the control group,and there was a significant difference between the two groups(P<0.01).?The efficacy of traditional Chinese medicine syndrome,the total effective rate of the treatment group is 96.7%,the total effective rate of the control group is 70%,there was a significant difference between the two groups(P<0.01).Carotid ultrasound:?There was no significant difference in plaque area between the two groups after treatment(P>0.05),there was a significant difference between the two groups after treatment(P<0.05),the plaque area of the treatment group was smaller than that of the control group.?There was no significant difference between the two groups before and after treatment in the plaque score group,and there was no significant difference between the two groups after treatment(P>0.05).?There was no significant difference between the two groups before and after treatment in the IMT group,and there was no significant difference between-the two groups after treatment(P>0.05).?There was no significant difference between the two groups before and after the Crouse score group,and there was no significant difference between the two groups after treatment(P>0.05).?Comparison of clinical efficacy of carotid color Doppler ultrasound before and after treatment between the two groups,there was no significant difference between the clinical effects of plaque score,IMT and Crouse score(P>0.05).After treatment,the clinical efficacy of the plaque area was 56.7%in the treatment group and 26.7%in the control group.There was a significant difference between the groups(P<0.05).Lipid index:?There was no significant difference in the changes of blood lipid index between the two groups after treatment(P>0.05).?The LDL-C compliance rate was 3.3%in the treatment group and 0%in the control group.There was no significant difference between the two groups(P>0.05).Cardiac ultrasound index:?There was no significant difference in LVIDd between the two groups before and after treatment,and no significant difference between the two groups after treatment(P>0.05).?There was no significant difference in IVS between the two groups before and after treatment,and no significant difference between the two groups after treatment(P>0.05).?The LVPW of the two groups decreased significantly after treatment compared with before treatment,there was a significant difference between the groups(P<0.01),and no significant difference between the groups(P>0.05).?The LVEF of the two groups was compared before and after treatment.There was no significant difference in the control group(P>0.05),there was a significant difference in the treatment group(P<0.05),and there was no significant difference between the two groups after treatment(P>0.05).The difference between before and after LVEF treatment was compared between groups.The improvement in the treatment group was more obvious than that in the control group,with significant differences(P<0.05).Safety evaluation:Before and after treatment in both groups,there were no drug-related abnormal liver and kidney function indexes and adverse events.Conclusion:Buxinruanmai(BXRM)granule combined with western medicine can significantly improve the clinical symptoms of patients with stable coronary heart disease and carotid atherosclerosis,reduce the area of carotid plaque,improve the left ventricular ejection fraction,and has good safety.