| ObjectiveThe incidence of coronary heart disease and mortality are increased year by year, the disease including acute coronary syndrome (ACS) and stable coronary artery disease (CAD). Patients with stable coronary heart disease may be due to the severe inflammation, the artery atheromatous plaque rupture, acute thrombosis and acute coronary syndrome. Therefore, inhibiting the inflammatory response in patients with stable coronary heart disease, reduce the chance of plaque rupture, will effectively reduce the incidence of acute coronary syndrome, without proper treatment is can aggravate the burden of family and community health. According to statistics, at present, the number of dyslipidemia> 200 million, and the number is still rising, dyslipidemia accelerates occurrence and development of atherosclerosis. And dyslipidemia, atherosclerosis are risk factors for coronary heart disease (CHD) and caused serious influence the quality of the survival of patients. Therefore, to seek a suitable control scheme will be cardiovascular physicians are the immediate problem. Western medicine lipid drug emerge in endlessly, although statins regulate blood lipid for atherosclerosis progress play a deterrent, but the side effects of cases, the hard to avoid in the process of taking also cannot be ignored. To meet the standard application and high-dose statin therapy of liver and kidney function damage, gastrointestinal adverse reactions and rhabdomyolysis risk gradually exposed the limitations of its use, in the disease prevention and control of traditional Chinese medicine has accumulated certain experience, to some extent is addition to the western medicine, and clinical studies confirmed that Chinese medicine in the regulation of blood lipids, reverse atherosclerotic plaque, etc, curative effect is certain. To seek a more safe, practical and effective treatment is still a clinical medical staff s responsibility.The disease can be attributable to the traditional Chinese medicine (TCM) "obstruction of qi in the chest", "single heart" and "really painful" category, such as the mechanism in this paper, the first in synopsis of vein obstruction of heartache dispirited disease syndrome cure ". This disease, and liver, spleen, kidney and other viscera function disorder is closely related to disease belong to the virtual standard empirical. This deficiency is given priority to with viscera qi and blood deficiency, mark but with phlegm turbidity and blood stasis certification of deterring chest Yang, block heart arteries and veins.In this study, on the basis of Chinese medicine dialectical, according to the Yi Qi Huo Xue Qu Tan Fa, adopts the traditional Zhibitaii capsule treatment of qi deficiency and blood stasis phlegm obstruction type, patients with stable coronary heart disease associated with carotid plaques in patients with blood lipid four, alanine aminotransferase, creatinine, uric acid, creatine kinase and carotid artery colour to exceed the results to observe the clinical curative effect, center the treatment of this disease are discussed the feasibility, effectiveness and safety of drugs.MethodsAltogether select 60 patients with qi deficiency blood stasis phlegm obstruction type patients with stable coronary heart disease associated with carotid plaques, simple to use digital method,60 cases were randomly divided into two groups at random,30 cases in each group, a total of 60 cases. On the basis of conventional western medicine therapy, treatment group will be fat ty capsule 0.48 g bid and simvastatin 10 mg qN, control group given simvastatin 20 mg qN, total treatment for 3 months. Were observed before and after treatment in both groups of carotid plaques, blood lipids (TC, TG, HDL, LDL), alanine aminotransferase (ALT), creatinine (CR), uric acid (UA) and the changes of creatine kinase (CK), record the relevant data.ResultChanges in carotid plaques:after treatment, two groups of patients with carotid artery plaque, the plaque integral number, thickness in the carotid artery-were significantly decreased (P<0.05). In comparison with the results of the two groups before and after treatment, there are significant differences (P<0.05), the therapeutic effect of treatment group was superior to that of the control group.Blood lipid changes:the two groups after treatment in patients with total cholesterol, triglyceride, low density lipoprotein cholesterol (hdl-c) significantly decreased (P<0.05), high density lipoprotein increased significantly (P<0.05), and compare the results of the two groups before and after treatment, there were significant differences (P<0.05), the treatment group curative effect surpasses the control group obviously.ALT, CR and UA, CK changes:two groups of patients after treatment of ALT, CR and UA, CK was higher, the rise has obvious difference (P<0.05). Compared with the treatment group, control group ALT, CR and UA, CK increase is more significant difference (P<0.01).ConclusionThe Zhibitai capsule combined simvastatin can effectively reduce the deficiency of blood stasis phlegm obstruction type number of carotid plaques patients with stable coronary heart disease, reduce the thickness of the membrane in the carotid artery -and carotid artery plaque integral, and can effectively reduce the TC, TG, LDL, increase the role of HDL, the cutting statin treatment, the clinical curative effect is superior to the simvastatin is a more effective method for clinical treatment. |
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