| Purpose: To observe the clinical effectiveness and safety of staging the prescription of the Dai doctors prescription Agreement for the treatment of gouty arthritis,providing the clinical data of gout prevention and treatment using drugs in Dai medicine,lay the experimental foundation for the development of Dai medicine for gout treatment.Method:A randomized control method was used to collect 240 cases of gouty arthritis patients who met the inclusion criteria in the outpatient department of Yunnan Traditional Chinese Medicine Hospital,120 cases in the acute phase(the superabundance of wind-fire),and the intermittent period(the imbalance of earth tower),each period was randomized Divided into 60 cases in the test group and 60 cases in the control group;the acute phase test group was given oral Keluofengfengxiaozhong Decoction,and the control group was given oral colchicine tablets for 5 days as a course of treatment;the intermittent period test group was given oral Mogunbutu Huoxue Zhitong Decoction,the control group were given oral benzbromarone tablets for 3 months as a course of treatment;by observing the Dai's syndrome scores before and after treatment,blood uric acid,erythrocyte sedimentation rate,C-reactive protein levels and other therapeutic indicators and safety Sex index,to explore the clinical efficacy and safety of the Dai medicine agreement prescription staged treatment of gouty arthritis.Result:Acute phase:1.Before treatment,there was no statistically significant difference between the test group and the control group in terms of general conditions(gender,age,course of the attack),laboratory indicators(blood uric acid,erythrocyte sedimentation rate,C-reactive protein),and points of Dai's medical syndrome Significance,the two groups are comparable(P> 0.05).2.After treatment,the points of Dai's medical syndromes of the two groups decreased significantly,and the difference before and after treatment was statistically significant(P<0.05);between groups,the test group's points of Dai's medical syndromes decreased more significantly than the control group.It has statistical significance(P <0.05).3.After treatment,the levels of erythrocyte sedimentation rate and C-reactive protein in the two groups decreased significantly,and the difference before and after treatment was statistically significant(P <0.05);between the groups,the level of erythrocyte sedimentation rate and C-reactive protein in the control group decreased more than in the test group To be significant,the difference was statistically significant(P <0.05).4.After treatment,the comprehensive efficacy of the two groups of patients was compared between the groups.The total effective rate in the test group was 86.7%,and the total effective rate in the control group was 93.3%.The difference was statistically significant(P <0.05).5.After treatment,there was no statistically significant difference in safety indicators(liver and kidney function,electrolytes,blood glucose,three routines)between the two groups(P> 0.05),and the difference in gastrointestinal adverse reactions between the two groups was statistically significant(P < 0.05).Interval period:1.Before treatment,there was no statistically significant difference between the test group and the control group in terms of general conditions(gender,age),laboratory indicators(blood uric acid,erythrocyte sedimentation rate,C-reactive protein),and points of Dai's medical syndrome.Comparability(P> 0.05).2.After treatment,the points of Dai's medical syndrome of the two groups decreased slightly.The difference between the test group before and after treatment was statisticallysignificant(P <0.05),the control group had no statistical significance(P> 0.05);the comparison between the groups,the test The score of Dai's medical syndrome in the group was more significant than that in the control group,and the difference was not statistically significant(P> 0.05).3.After treatment,the blood uric acid level of the two groups of patients decreased significantly,and the difference before and after treatment was statistically significant(P<0.05);between the groups,the blood uric acid level of the control group decreased more than the test group,and the difference was statistically significant(P <0.05).4.After treatment,the erythrocyte sedimentation rate and C-reactive protein levels of the two groups decreased slightly.The difference between the test group before and after treatment was statistically significant(P <0.05),the control group had no statistical significance(P> 0.05);The levels of erythrocyte sedimentation rate and C-reactive protein in the test group were more significant than those in the control group,and the difference was statistically significant(P <0.05).5.After treatment,the comparison between the two groups of patients,the number of acute gout attacks in the test group was significantly reduced compared with the control group(P <0.05).6.After treatment,between groups,the control group's blood uric acid compliance rate(the proportion of patients whose blood uric acid fell below 360 ?mol / L)was significantly higher than that of the test group,and the difference was statistically significant(P <0.05).7.After treatment,there was no statistically significant difference in safety indicators(liver and kidney function,electrolytes,blood glucose,three routines)between the two groups(P> 0.05),and the difference in adverse reactions between the two groups was statistically significant(P <0.05).In conclusion:1.Keluoleifeng Xiaozhong decotion is able to effectively improve the clinical symptoms and signs of patients with sand throat(the superabundance of wind-fire),improve laboratory indicators,and find no obvious adverse reactions.It is effective andsafe and worthwhile.Further research and promotion.2.Mogubutuhuoxuezhitong decoction is able to be used for lowering uric acid in patients with sand throat(the imbalance of earth tower),can effectively improve patients' blood uric acid,erythrocyte sedimentation rate,C-reactive protein levels,reduce the number of gout attacks,and has anti-inflammatory lowering uric acid No obvious adverse reactions have been found,and it is effective and safe.In the future,it may be appropriate to increase the course of treatment for further research and promotion. |
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