Clinical Study Of Modified Sangbaipi Decoction In The Treatment Of Elderly AECOPD(Phlegm-heat Stagnation Lung Syndrome)

Objective:To study the clinical efficacy of Modified Sangbaipi Soup in treating elderly patients with AECOPD and its influence on D-dimer,so as to provide objective facts to optimize clinical treatment solutions.Methods:The elderly AECOPD patients,from January,2019 to December,2019,admitted to the Department of Geriatrics and Department of Pulmonary Diseases of NO.1 Affiliated Hospital of Yunnan University of Chinese Medicine,according to TCM differentiated as Phlegm-heat Stagnation Lung Syndrome,were divided into two groups—with 36 cases in the Control Group,and 36 cases in the Treatment Group—according to the random number table.The Control Group was treated with symptomatic treatment,such as controlled oxygen therapy,anti-infective therapy,bronchodilator,using glucocorticoid as demanded and phlegm-eliminating therapy,etc.The Treatment group,except the above-mentioned treatments,added the Modified Sangbaipi Soup treatment,whose course is 10 days.Data of clinical syndromes score,physical signs score,D-dimer,pulmonary function,chest X-ray,and safety index were respectively recorded before and after the treatment.All the data were assessed by statistical analysis for therapeutic effect evaluation.Results:?1?The total effective rate of Treatment Group was 90%,which is higher than that of Control Group—74.19%.The difference was statistically significant?P<0.01?.?2?The total scores of clinical symptoms and physical signs both went down in the two groups.The difference was statistically significant?P<0.01?.By comparing between the two groups after treatment,Treatment Group was significantly better than Control Group,the difference was statistically significant?P<0.01?.By comparison within groups,such as cough,phlegm,wheezing,thirsty and favored cold drinks,pulmonary rales,fever,and shortness of breath,the difference before and after the treatment was statistically significant?P<0.01?.However,there was no statistically significant difference before and after treatment in Control Group in the improvement of cyanotic lips,chest pain,and constipation?P>0.05?.There was significant statistical difference in the Treatment Group?P<0.05?.By the comparison between groups before and after treatment in terms of single symptoms and physical signs,Treatment Group performed better than Control Group,the difference was statistically significant?P<0.05?.?3?There were statistically significant differences in lung function,before and after treatment,within both of the two groups?P<0.01?.After the treatment,comparing the therapeutic effectiveness of FEV₁%between the two groups,the difference was statistically significant?P<0.05?.Treatment Group performed better than Control Group,while the difference of FEV₁/FVC?%?between the two groups was not statistically significant?P>0.05?.?4?Both groups reduced D-dimer level,the difference was statistically significant?P<0.05?.Treatment Group performed better than Control Group.?5?The relationship between D-dimer level and FEV₁%was negatively correlated?P<0.01?in both of the two groups.The relationship between lung function severity and D-dimer was positively correlated?P<0.01?.?6?In the aspect of improving Chest X-ray,the Treatment Group performed better than the Control Group,the difference was statistically significant?P<0.01?.Conclusion:Modified Sangbaipi Soup has significant curative effect on the elderly AECOPD?Phlegm-heat Stagnation Lung Syndrome?patients with good safety,which can effectively control lung inflammation and better improve the symptoms of chest tightness and pain,cyanotic mouth and lips,and constipation,etc.D-dimer can work as an indicator of syndrome severity for necessary early intervention.