Clinical Research On The Treatment Of Postmenopausal Osteoporosis By Prescription On Tonifying Kidney And Nourishing Liver And Bone

Objective:Under the guidance of the tutor"He Chang Thought",with the experience of the tutor,prescription on tonifying kidney and nourishing liver and bone for the treatment of postmenopausal osteoporosis with hepatic and renal deficiency,by observing the changes of clinical symptoms,bone density,and laboratory indicators,explore prescription on tonifying kidney and nourishing liver and bone in the treatment of this disease provide more ideas and methods for clinical treatment of this disease with traditional Chinese medicine.Methods:Into accord with kidney deficiency type 67 patients with postmenopausal osteoporosis were randomly divided into treatment group?kidney nourishing the liver JianGu party+calcium carbonate D₃+afar vitamine D₃ capsules?34 cases,in the control group?calcium carbonate D₃+afar vitamine D₃ capsules?33 cases,medication after three course,observe two groups of patients before and after treatment of clinical symptoms,bone mineral density?BMD?,25-hydroxyl vitamin D?25-OH-D?,estradiol?E₂?,follicle-stimulating hormone?FSH?,after statistics analysis,evaluate the clinical curative effect,observe its safety.Results:1.Comparison of improvement of clinical symptoms:?1?overall efficacy of traditional Chinese medicine:the total effective rate of the treatment group was 90%after treatment;The total effective rate of the control group was 70%after treatment.The curative effect of the treatment group was better than that of the control group?P<0.01?.?2?total score of TCM clinical symptoms:before and after treatment,the total score of the two groups was lower than that before treatment?P<0.01?.The treatment group was superior to the control group?P<0.01?.?3?the doctor of traditional Chinese medicine clinical symptom scores:the two groups before and after treatment group,treatment group can obviously improve the lower back pain,lumbar debility weakness,lower limb pain,leg cramps,tinnitus,dizziness,hot flashes,night sweats,insomnia,much dream symptoms?P<0.01?,the control can improve the low back pain,lumbar debility weakness,lower limb pain,leg cramps symptoms?P<0.01?,to improve the tinnitus,dizziness,hot flashes,night sweats,insomnia,much dream symptoms differences had no statistical significance?P>0.05?;Comparison between the two groups after treatment showed that the treatment group was significantly better than the control group in improving lumbago and back pain,lumbago and knee weakness,dizziness,insomnia and dreaminess?P<0.05?and tinnitus and hot flashes and night sweats?P<0.01?.The two groups were equally effective in improving lower limb pain and cramping?P>0.05?.2.Comparison of BMD and laboratory indexes:?1?BMD:in the treatment group was higher than that before treatment?P<0.01?,while that in the control group was higher than that before treatment?P<0.05?.Compared with the control group after treatment,the treatment group was superior to the control group?<0.05?.?2?25-OH-D:the comparison between the two groups of 25-OH-D group was higher than that before treatment?P<0.01?.After treatment,the two groups were compared and the curative effect was similar?P>0.05?.?3?E₂ and FSH:E₂ in the treatment group was increased and FSH was decreased?P<0.01?.The difference of E₂ and FSH in the control group was not statistically significant?P>0.05?.After treatment,the improvement of E₂ and FSH in the treatment group was significantly better than that in the control group?P<0.01?.3.Comparison of comprehensive efficacy:in the treatment group,0 cases recovered,11cases showed obvious efficacy,14 cases were effective,and 5 cases were ineffective,with a total effective rate of 83.3%.In the control group,0 cases were cured,2 cases were effective,18 cases were effective and 10 cases were ineffective after treatment,and the total effective rate was 66.7%.The comprehensive efficacy of the treatment group was better than that of the control group?P<0.01?.4.Safety indicators:there were no abnormal safety indicators in the two groups of subjects in this study.Conclusion:1.The tutor believes that the occurrence of PMOP is mainly due to the"dissonance"of liver and kidney viscera blood,essence blood,yin and yang,meridians,and organs.2.Prescription on tonifying kidney and nourishing liver and bone was formulated by the instructor on the basis of"hechang thoughts"and zuogui pill.It aims to make qi and blood,jingxue,Yin and Yang,meridians and viscera smooth,so as to improve PMOP and improve the patient's quality of life.3.Prescription on tonifying kidney and nourishing liver and bone combined with bone nutrition supplement can effectively improve patients'lower back and lower limb pain,lower back tenderness and weakness,lower limb cramps,tinnitus,dizziness,hot flashes,night sweats,insomnia and dreaminess.4.Prescription on tonifying kidney and nourishing liver and bone combined with bone nutrition supplement can effectively improve the bone mineral density and vitamin D level of patients,and adjust the hormone level to increase E₂ and decrease FSH.5.Based on"hechang thought",prescription on tonifying kidney and nourishing liver and bone is used to treat this disease,and its clinical effect is positive.No obvious adverse reactions or toxic side effects are seen in the treatment,so it is worth popularizing and applying.