To Explore The Expression And Significance Of DBC1?P53 And MDM2 In Human Colorectal Cancer

Objective:To detect the expression levels of DBC1,P53,and MDM2 in 43colorectal cancer tissues and adjacent non-cancerous tissues,and to correlate with the clinical and pathological characteristics of colorectal cancer,and provide new evidence for the treatment of colorectal cancer.Methods:On the premise of meeting the selection conditions,the wax blocks of tumor tissues and adjacent non-cancerous tissues of 43 patients with colorectal cancer confirmed by postoperative pathology in Second Affiliated Hospital of University of South China from 2014 to 2019 were selected.By immunohistochemical method,detect whether the expression levels of DBC1,P53,MDM2 in colorectal cancer and adjacent non-cancerous tissues are different;whether their expression levels are related to the clinicopathological characteristics of colorectal cancer;the three proteins in the colorectal cancer Whether there was a correlation between expression in rectal cancer.Results:(1)The positive expression rates of DBC1 in the colorectal cancer group and adjacent non-cancer tissue groups were 83.7%(36/43)and 60.5%(26/43).The difference between the two groups was statistically significant(?~2=5.780,P=0.016);there was no correlation between the expression level of DBC1 and the relevant clinicopathological characteristics(sex,age,tumor size,depth of invasion,metastasis,degree of differentiation,TNM stage)of colorectal cancer(P>0.05).(2)The positive expression rates of P53 in the colorectal cancer group and adjacent non-cancer tissue groups were 69.8%(30/43)and 2.3%(1/43);The difference between the two groups was statistically significant(?~2=42.420,P=0.000);There was no correlation between the expression level of P53and the relevant clinicopathological characteristics(sex,age,tumor size,depth of invasion,metastasis,degree of differentiation,TNM stage)of colorectal cancer(P>0.05).(3)The positive expression rates of MDM2 in the colorectal cancer group and adjacent non-cancer tissue groups were 65.1%(28/43)and 34.9%(28/15);The difference between the two groups was statistically significant(?~2=7.860,P=0.005);There was no correlation between the expression level of MDM2 and the relevant clinicopathological characteristics(sex,age,tumor size,depth of invasion,metastasis,degree of differentiation,TNM stage)of colorectal cancer(P>0.05).(4)There was no correlation between the expression of DBC1 and MDM2 in colorectal cancer(P=0710);there was no correlation between the expression of P53and MDM2 in colorectal cancer(P=0.717);There was no correlation between the expression in colorectal cancer(P=0.327).Conclusion:(1)The three proteins DBC1,P53,and MDM2 are overexpressed in colorectal cancer tissues,suggesting that these three proteins may play a role in promoting cancer in colorectal cancer;(2)There was no significant correlation between the expressions of DBC1,P53,and MDM2 proteins in colorectal cancer.