Clinical Study Of Qinggan Quzhi Recipe In Treating Non-alcoholic Steatohepatitis With Internal Resistance Of Phlegm And Dampness

Objective : This subject aims to explore the clinical efficacy of Qinggan Quzhi Recipe in the treatment of non-alcoholic steatohepatitis(phlegm-damp internal resistance type),to providing the corresponding clinical basis for this disease.Methods:According to the inclusion criteria,60 patients were randomized and controlled clinically.They were divided into a treatment group and a control group,of which 1 case fell out of the treatment group and 59 cases were finally completed(30 cases in the control group and 29 cases in the treatment group).On the basis of diet control and exercise enhancement,the control group was given polyene phosphatidylcholine capsules(3 capsules 3times a day)plus diammonium glycyrrhizinate enteric capsules(2 capsules 3times a day)orally;The group was given Qinggan Quzhi Decoction,one dose per day,which was taken twice.Both courses of treatment were 12 weeks.I observed and observed the TCM syndrome scores,liver function indexes(ALT,AST),blood lipid indexes(TG,TC),liver color Doppler ultrasound results,BMI index,controlled attenuation parameter CAP value and clinical symptoms And other relevant changes,then I conducted a statistical analysis and efficacy evaluation.Results:1.The total effective rate in the treatment group was 82.76%,and thetotal effective rate in the control group was 70.00%.The treatment group was better than the control group(P<0.05).Before and after treatment,the two groups were obese,right flank swelled,heavy body,sticky and unpleasant stools,abdominal distension,and loss of appetite(P<0.05),while fatigue and dizziness and dizziness were compared(P>0.05).Comparison of TCM syndromes between groups(P<0.05).2.After treatment,the ALT and AST values of both groups decreased,compared with before treatment(P <0.05);between the groups,the treatment group was better than the control group(P <0.05).3.After treatment,the TG and TC values of both groups decreased,compared with before treatment(P <0.05);between the groups,the treatment group was better than the control group(P <0.05).4.After treatment,the BMI index of the two groups of patients decreased,compared with that before treatment(P<0.05);between the two groups,the two groups had the same effect on improving the BMI index(P>0.05).5.Liver color Doppler ultrasound grading results of the two groups of patients after treatment,the effective rate of the treatment group was 79.31%,the total effective rate of the control group was 66.67%,and the treatment group was better than the control group(P<0.05).6.The CAP values of the controlled attenuation parameters of both groups decreased after treatment.The effective rate of the treatment group was82.75%,the effective rate of the control group was 73.33%,and the treatment group was better than the control group(P<0.05).7.There were no adverse reactions in the two groups before and after treatment,and the safety was good.Conclusion:1.Qinggan Quzhi Recipe can significantly improve the clinical symptoms and signs of patients with non-alcoholic steatohepatitis;2.Qinggan Quzhi Recipe can reduce blood lipids(TG,TC),CAP value,improve liver function(ALT,AST)and liver color Doppler ultrasound pathology,indicating that Qinggan Quzhi Recipe can inhibit lipid peroxide in the liver and reduce blood lipids,The effect of protecting the liver,and the effect is better than polyene phosphatidylcholine capsules + diammonium glycyrrhizinate enteric capsules.3.Qinggan Quzhi Recipe is effective and safe,and is worthy of clinical promotion and application.