| Objective: To observe the clinical efficacy and safety of Zhuang Yao Gu Bi Fang ironing combined with quadriceps exercise in the treatment of knee osteoarthritis(KOA)in early and middle stages,and to provide a basis for its further clinical promotion.The effect of therapy on patients’ serum 5-hydroxytryptamine(5-HT)and interleukin-6(IL-6),explore the possible treatment of knee osteoarthritis by Zhuang Yao Gu Bi Fang ironing combined with quadriceps exercise Mechanism of action.Methods: Sixty-eight early and mid-term KOA patients who were treated in the joint trauma orthopedics clinic of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from May 2019 to November 2019 were randomly divided into experimental and control groups,with 34 cases in each group.The test group used Zhuang Yao Gu Bi Fang ironing combined with quadriceps exercise,and the control group used a simulated agent ironing combined with quadriceps exercise.The course of treatment was 2 weeks.Changes in serum 5-HT and IL-6 levels were measured before and after treatment.At the same time,the changes in VAS score,WOMAC score,and KOA symptom quantification score were evaluated at the two time points.The research data obtained were analyzed by SPSS 26.0 software.Chi-square test was used for comparison of count data.For measurement data,paired t-test was used for comparison of self-mean values before and after treatment within the group,and t-test or t ’test was used for comparison between groups.Rank sum test was used for graded data.The inspection level is α = 0.05.Results:1.Overall condition: Before treatment,there was no significant difference in the age,sex,duration of disease,VAS score,WOMAC score,quantified score of knee osteoarthritis symptoms,and serum 5-HT and IL-6 levels in the test group and the control group.Comparable;68 patients included in this study completed the corresponding course of treatment,no cases of shedding,and no serious adverse reactions.2.Comparison within the group: End of treatment,the two groups of patients’ own VAS score,WOMAC score and KOA symptom quantification scores were all reduced,the difference was statistically significant,indicating that Zhuang Yao Gu Bi Fang ironing combined with quadriceps exercise and simulation agent Both ironing and quadriceps exercise can alleviate knee pain and improve joint mobility.The levels of serum 5-HT and IL-6 in the two groups were lower than before treatment,and the difference was statistically significant,indicating that the treatment of the two groups Can reduce the levels of serum pain factors and inflammatory factors in patients.3.Comparison between groups: At the end of treatment,the total effective rate was 94.1% in the experimental group and 73.5% in the control group.the WOMAC score,quantified score of knee osteoarthritis symptoms,and serum IL-6 content in the experimental group were lower than those in the control group,and the differences were statistically significant,indicating that Zhuang Yao Gu Bi Fang Ironing combined with ironing Quadriceps exercise has more advantages in improving knee function and overall quality of life of patients;there is no statistically significant difference in the VAS score and serum 5-HT content between the experimental group and the control group,indicating that the two are alleviating joint pain in patients.There is little difference in efficacy.Conclusions:1.Zhuang Yao Gu Bi Fang ironing combined with quadriceps exercise for the treatment of KOA in early and mid-term is reliable and safe,which can effectively alleviate the symptoms of knee joint pain and improve joint mobility.2.Zhuang Yao Gu Bi Fang ironing combined with quadriceps exercise can reduce the serum 5-HT and IL-6 levels in patients,which may be one of its mechanisms of treatment for early and mid-term KOA.3.There were no serious adverse events in the experimental group and the control group,which confirmed that the interventions used in this study had good safety. |
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