Study On The Correlation Between Imbalance Of Vaginal Microenvironment And HR-HPV Infection

Objective:Cervical cancer has been recognized as a malignant tumor often caused by hr-hpv infection,and is the most common gynecological cancer in the world.Repeated and persistent high-risk human papillomavirus(hr-hpv)infection is the main cause of cervical cancer and medium-high cervical intraepithelial neoplasia(CINII/III)in women.Now the study found that the vaginal microecological in preventing bacterial vaginosis and urinary tract infection related microbial settled and has an important role in the process of excessive breeding,also can reduce some sexually transmitted diseases(HIV,mycoplasma,chlamydia,herpes simplex virus,gonorrhea diplococcus and vaginal trichomoniasis bacteria,etc.)of transmission and the risk of infection.Studies have shown that disorders of the microecology of the vagina(bacterial flora,PH,etc.)reduce the immune system’s ability to clear the infection,which in turn increases the risk of hr-hpv infection.This research group collected the medical history data of the fifth joint examination of vaginal secretions and HPV test in our hospital,and through comparative analysis and summary of the correlation between the changes of the vaginal microenvironment and hr-hpv infection,provided clinical basis for the prevention of hr-hpv infection and the progress of cervical cancer caused by persistent HPV infection,and provided new ideas for the treatment of HPV infectionMethods:This study retrospectively analyzed the medical history data of the patients who underwent the five-way examination of vaginitis and cervical HPV test in the gynecological outpatient department of our hospital,and analyzed the differences between the abnormal indicators of vaginal microenvironment and hr-hpv infection,so as to study the correlation between the change of vaginal microenvironment and HPV infection.Result:By analyzing hr-hpv infection in different abnormal vaginal environments,the results showed that hr-hpv positive rate was found in 200 patients with positive BV[75 cases(37.5%)]and hr-hpv positive rate in 408 patients with negative BV[115 cases(27.5%%)].The difference was statistically significant(x2=6.364 P=0.012).However,the hr-hpv positive rate of 91 patients with VVC was not statistically significant(x2=0.246 P=0.620),and the hr-hpv positive rate of 517 patients with VVC negative was not statistically significant(157 cases(30.4%)).PH value> in 182 cases;4.5 hr-hpv positive rate of patients[73 cases(40.1%)]and hr-hpv positive rate of 426 cases(114 cases(26.8%)]with normal PH,the difference was statistically significant(x2=10.670 P=0.001).The positive rate of hr-hpv in 61 patients with abnormal lactobacillus was 27(44.3%),and the positive rate of hr-hpv in 547 patients with normal lactobacillus was 160(29.3%),and the difference was statistically significant(x2=5.807 P&1t;0.016).Among the 132 sialidase positive patients,52(39.4%)were hr-hpv positive,and 135(28.4%)were hr-hpv positive among 476 sialidase negative patients.The difference was statistically significant(x2=5.906;P=0.015).Among 232 cases of leucocyte esterase positive patients,85(36.6%)were hr-hpv positive patients,and among 376 cases of leucocyte esterase negative patients,102(27.1%)were hr-hpv patients.The difference was statistically significant(x2=6.093;P=0.014);Among the 121 patients with aceaminosaminidase positive,44(36.4%)were hr-hpv positive,and among the 487 patients with aceaminosaminidase negative,143(29.4%)were hr-hpv positive.The difference was not statistically significant(x2=2.230;P=0.135);Among the 99 cases of proline aminopeptidase positive patients,36(36.4%)were hr-hpv positive,and among the 509 cases of proline aminopeptidase negative patients,151(29.7%)were hr-hpv positive.The difference was not statistically significant(x2=1.746;P=0.186)Conclusion:(1)imbalance of the vaginal microenvironment,especially the abnormal increase in the PH value of the vagina,the absence or dysfunction of lactobacillus,and bacterial vaginosis are positively correlated with cervical hr-hpv infection.(2)improving the vaginal microenvironment may reduce high-risk HPV infection in the genital tract and provide new ideas for cervical cancer prevention.