Correlation Analysis Between Changes Of Vaginal Microenvironment And Different Grades Of Cervical Lesions

OBJECTIVE: To study the role of vaginal microenvironment changes in the development of high-risk HPV infection and cervical lesions in the cervix,and to analyze the high-risk factors of different levels of cervical lesions,and to provide evidence for early treatment and prevention of cervical lesions.METHODS: A total of 451 women with sexual life who were admitted to the gynaecological clinic of the Affiliated Hospital of Hebei University from June 2017 to December 2018,aged 25 to 60 years,were selected for cervical exfoliation cytology(TCT)and HPV(PCR-Reverse dot blotting),patients with positive TCT detection(ASCUS and above)or(and)high-risk HPV were included in the experimental group,and all underwent a colposcopy cervical biopsy.According to the pathological results,the patients were divided into cervical lesions(Low-grade disease group,high-grade disease group),cervical cancer group and chronic cervicitis group,among which: CINI 93 cases of cervical low-grade disease group,cervical high-grade disease group including 78 cases of CINII and 141 cases of CINIII 63 cases,14 cases of cervical cancer group,chronic In the cervicitis group,203 patients were treated with HPV and TCT negative patients in the same period as the control group.The HPV infection status of each group was compared,and the PH value of the vaginal microenvironment,leukocyte esterase,catalase and pathogens were compared.Situation,analysis of the results obtained.RESULT:1.Age comparison of each group: There was no significant difference in age between the control group,chronic cervicitis group,cervical low-grade disease group and cervical high-grade disease group(P>0.05),while the age of cervical cancer group was statistically compared with the other four groups.Learning differences(P <0.05).2.HPV infection in the experimental group: Among the 451 patients in the experimental group,the high-risk HPV infection rate was 92.83%,and the highest genotypes were: 16,52,18,58.3.Detection of vaginal microenvironment: The difference of pH value between the control group,chronic cervicitis group,cervical low-grade disease group and cervical high-grade disease group was statistically significant(P=<0.05),and the high-grade disease group was compared with the other three groups.There were statistical differences between the control group and the low-grade disease group.In the comparison of catalase,the difference between the high-grade disease group and the other groups was statistically significant.The difference between the other three groups was not statistically significant.In the comparison of leukocyte esterase,the difference between the high-grade lesion group and the other groups was statistically significant.There was no significant difference between the other three groups.There was no significant difference in trichomoniasis and VVC infection among the four groups(P= 0.337>0.05,P=0.749>0.05);In the comparison of BV,the difference between the high disease group and the other groups was statistically significant.The difference between the low disease group and the control group was statistically significant,and the difference between the other groups was no difference.Statistical significance.CONCLUSIONS:1.HPV16 infection is a risk factor for the progression of cervical lesions.High-risk type 52 and 58 infections may be associated with low-grade cervical lesions.2.The more severe the cervical lesions,the higher the pH value in the vaginal microenvironment,which corresponds to the reduction of vaginal lactic acid bacteria,the increase of leukocyte esterase,and the increase of pH is an important risk factor for the development of cervical lesions.3.BV may play a role in the development of high-grade lesions of the cervix,but it is not yet known that trichomoniasis and VVC are associated with cervical lesions.