Study On The Relationship Between Helicobacter Pylori And Parkinson's Disease

Background and Objective:Parkinson's disease(PD)is a type of neurological dyskinesia disease that is more common in the middle-aged and elderly people.It is insidious onset,chronic progression,and the first symptom is motor symptoms.Its pathological feature is dense midbrain substantia nigra the dopaminergic neurons in the part degenerate and gradually decrease,which causes the dopamine in the striatum to gradually decrease.When it reaches a certain level,dopamine and acetylcholine are out of balance.PD is a progressively worsening incurable disease,which places a huge burden on patients and families.It is hoped that breakthroughs can be made in its pathogenesis and pathogenic factors to find a way for the treatment and prevention of PD.It has been found that although PD is a neurological disease,it is closely related to the gastrointestinal tract.Studies have shown that PD may originate from the gut and spread to the central nervous system through the "brain-gut axis".Hidden infection of Helicobacter pylori(Hp)is an important cause of gastritis,ulcers and gastric cancer.But people are gradually discovering that H.pylori is also involved in diseases outside the digestive system.Schwab first described the increased incidence of gastric ulcers in patients with PD in 1961,and found that patients with gastric ulcers were more likely to develop PD than those without H.pylori infection.The purpose of this study is to explore the relationship between Hp infection and the pathogenesis and disease process of PD,and to further explore the effect of radical Hp on the therapeutic effect of PD,with a view to providing new methods and reference for clinical treatment of PD.Methods:Eighty patients with Parkinson's disease who were hospitalized in the Department of Neurology,Zhengzhou Seventh People's Hospital from January 2018 to September 2019 were continuously collected as the PD group,and 80 healthy volunteers who had undergone physical examination in the hospital during the same period were selected as the control group.C13 breath test was performed.The Hoehn-Yahr(H-Y)rating scale and the Unified Parkinson's Disease Rating Scale motor part-?(UPDRS-?),that is,the exercise examination part,are used to assess the severity and motor function of PD to evaluate.? Compare the differences in gender,age,and Hp infection rate between the PD group and the control group,and analyze whether there is a correlation between Hp infection and the incidence of PD;? According to the results of the C13 breathing test,the PD components are divided into two groups:the Hp infection group and the non-Hp infection group.In the Hp infection group,the gender,age,course of disease,UPDRS-? score,UPDRS-?score,and H-Y classification were compared between the two groups,and whether there was a correlation between Hp infection and the severity of the disease in PD patients;Medoba was treated for 13 weeks.Hp infection group was further divided into two groups by random number table method:Hp radical group and non-radical group.In the Hp eradication group,the Hp quadruple therapy was given for 2 weeks at the same time as medoca treatment,and the C13 breathing test was reviewed 4 weeks after the end of the cure to determine whether the cure was successful.After 13 weeks of treatment,data were collected on the Hp-radical group,non-radical group,and non-infected group of PD patients,including UPDRS-? score,UPDRS-? score,and H-Y grade.Compared with the three groups,UPDRS-? after 13 weeks of treatment,UPDRS-?,H-Y classification,reduction rate,evaluate the overall efficacy of the three groups of patients,analyze whether there is a correlation between the effect of Hp infection on the treatment of PD,and analyze whether there is any change in the treatment effect of PD after Hp eradication.At the same time,in order to exclude the effect of different doses of medoca on the results,a difference analysis of the three groups of doses was performed.? Statistical method:The collected data was entered into an Excel table,and the data was analyzed statistically using SPSS21.0 software.P<0.05 indicated that the difference was statistically significant.For descriptive statistics,the measurement data is expressed as mean ± standard deviation(x ± s),and the classification data is expressed as number of cases and percentage(%).The t-test was used for comparison between measurement data groups that met the normal distribution,and the non-parametric rank-sum test was used for those who did not meet the conditions;the chi-square test was used for comparison between count data groups;the non-parametric rank-sum test was used for comparison among rank data groups.Results:1.There was no significant difference in sex ratio,age,and C13 positive rate between PD group and control group(P>0.05).44 cases of C13 breath test positive in PD group(55%),36 cases of C13 breath test negative in PD group(45%),32 cases of C13 breath test positive in healthy control group(40%),48 cases of C13 breath test negative(60%).2.PD components were Hp infection group and non-Hp infection group.There was no significant difference in gender,age,course of disease,and UPDRS-IV score between the two groups(P>0.05);UPDRS-? score,H-Y before treatment in the two groups.There were significant differences in the classification and disease distribution(P<0.05),and the condition was more serious in the Hp infection group than in the non-Hp infection group.3.The Hp infection group was randomly divided into the Hp radical group and the Hp non-radical group.The Hp radical group,the Hp non-radical group,and the non-Hp infection group were treated with medoca for 13 weeks.The difference was statistically significant(P<0.05).the results of pairwise comparison between the groups:The difference between the Hp non-radical group and the Hp radical group is statistically significant(P<0.05);the difference between the Hp non-radical group and the non-Hp infection group is statistically significant.(P<0.05);there was no significant difference between the non-Hp infection group and the Hp radical group(P>0.05);that is,the curative effect of the Hp non-radical group was significantly lower than the other two groups.Conclusion:1.Hp infection may aggravate the condition of PD patients,which is mainly manifested by exacerbation of motor symptoms and decreased quality of life.However,the Hp infection rate of PD patients was not found to be significantly higher than that of the general population.2.H.pylori infection will affect the effectiveness of Medoba in treating PD.The total effective rate of Hp infection patients is lower than that of non-Hp infection patients,and the occurrence of motor complications is significantly more than that of non-infected patients.3.The curative effect of PD patients after Hp eradication is significantly better than that of Hp infection patients.It is effective in improving motor symptoms in PD patients,reducing motor complications in PD patients,and improving the overall efficiency of patients,but it improves the quality of life of patients.There is no obvious help,and the specific mechanism of action needs further research.