Study On The Correlation Between Helicobacter Pylori And Severity Of Motor Symptoms In Patients With Parkinson's Disease

Objective:Parkinson's disease?PD?is the second most common neurodegenerative disease.Its clinical manifestations include motor and non-motor symptoms.Progressive motor retardation,tremor,muscular stiffness,abnormal posture and gait seriously affect the life of the patients.Helicobacter pylori?HP?infection is a common infectious disease in the world,which is related not only to the occurrence of gastrointestinal diseases,but also to many systemic diseases,especially nervous system diseases.More and more studies have shown that Helicobacter pylori infection is associated with Parkinson's disease.Our study aimed to explore the correlation between Helicobacter pylori infection and the severity of motor symptoms in patients with Parkinson's disease,with a view to provide a new idea for the treatment of patients with Parkinson's disease.Method:80 patients?F 32,M 48?with PD from Department of Neurology,People's Hospital of Rizhao from January 2016 to February 2019 were collected.All cases met the clinical diagnostic criteria of brain bank of Parkinson's disease in England.At the same time,atypical Parkinson's syndrome,secondary Parkinson's syndrome,hereditary cases,patients who have undergone surgery,and patients with disease status known to affect13C breath test,HP antibody,vitamin B12 levels were excluded.The patients developed the disease for the first time without medication.80 cases?F 34,M 46?of health check-up in People's Hospital of Rizhao during the same period were selected as the control group.Individuals with disease status known to affect 13C breath test,HP antibody,vitamin B12levels were also excluded.General clinical data containing age,sex and age of onset were collected from the two groups.¹³C breath test was performed in the early morning empty abdomen.At the same time,the blood of the median elbow vein was collected for the measurement of HP antibody and vitamin B12 level of serum.The UPDRS part III score of Parkinson's disease was performed by specialists familiar with Parkinson's disease.The correlation between HP infection and UPDRS part III score,serum vitamin B12 level was analyzed.The collected data was analyzed using SPSS 24.0 software.Results:In general clinical data,there was no significant difference in sex between PD group and control group?p>0.05?.The mean age of PD group and control group were 56.41±4.68 years and 55.76±5.28 years,respectively.There was no significant difference between the two groups?p>0.05?.The UPDRS Part?score of PD group was 27.59±9.01.The positive rate of HP in PD group and control group was 66.3%and 37.5%,determined by Colloidal Gold method.The positive rate of HP in PD group was significantly higher than that in control group?P<0.05?.There was no significant difference in HP positive rate between male and female PD group?P>0.05?.The positive rate of HP in PD group and control group was 63.8%and 36.3%,determined by ¹³C breath test.The positive rate of HP in PD group was significantly higher than that in control group?P<0.05?.There was no significant difference in HP positive rate between male and female PD group?P>0.05?.The UPDRS Part?score of HP infected group in PD patients?29.08±8.54?was significantly higher than that of non-infected group?t=-0.119,p<0.05?.There was no significant difference in UPDRS Part III scores between men and women in HP infection group,determined by ¹³C breath test?P>0.05?.There was no difference in the serum vitamin B12 level between the case group and the control group?P>0.05?,and there was no difference in the serum vitamin B12 level between the HP infected group and the non-infected group?P>0.05?.There was no significant difference in serum vitamin B12 level between men and women in HP infection group of PD group,determined by¹³C breath test,in PD group?P>0.05?.Conclusions:Patients with PD had higher HP infection rate.HP infection could aggravate the degree of motor symptoms of patients with PD,and there was no significant difference between male and female.UPDRS part III score of HP infected group of patients with PD was significantly higher than that of non-infected group.HP infection might not be related to vitamin B12 in the pathogenesis of PD.