| Objective: The purpose of this study was to objectively evaluate the clinical efficacy of shenshenshenqdihuang decoction in the treatment of chronic urinary tract infection with deficiency and dampness-heat syndrome of qi-yin and qi-yin,summarize its medication rules,and observe its safety.To further explore and study the law of syndrome differentiation and treatment and optimal prescription of traditional Chinese medicine for the treatment of chronic urinary tract infection,so as to provide a new way of thinking for the reduction of antibiotics in the treatment of urinary tract infection.Methods :(1)the 84 patients who met the case criteria were randomly divided into the experimental group and the control group,with 42 patients in each group.(2)both groups received basic treatment of western medicine,including rest,diet,symptomatic treatment,and antibiotics as appropriate.On this basis,the experimental group was given zishenshenqidihuang decoction plus or minus treatment,one dose a day,400 ml water,taking warmly after breakfast and supper,the control group was given oral miniaoning capsules,3 capsules each time,3 times a day.(3)relevant efficacy and safety indicators were collected and analyzed before treatment and after3 weeks of continuous treatment.The observation indexes included the total score of TCM syndromes,single symptom score and laboratory test indexes such as urinary white blood cells,bacterial colony distribution in clean mid-course urine,etc.After treatment,the efficacy and safety of zishenshenqidihuang decoction in the treatment of chronic urinary tract infection were evaluated by comparison within and between groups.Results:(1)The curative effect of the disease: the total effective rate of the treatment group was 90%,and the total effective rate of the control group was 85%.The difference between the two groups was statistically significant(P<0.05).The clinical effect of the treatment group was more obvious.(2)in terms of syndrome efficacy,the total effective rate of the experimental group was 92.5%,and the total effective rate of the control group was 87.5%.The difference between the two groups was statistically significant(P < 0.05),and the clinical efficacy of the experimental group was more obvious.(3)syndrome score: the comparison between the two groupsbefore and after treatment and between the two groups after treatment showed statistically significant differences(P<0.05),indicating that the curative effect of the two groups after treatment was better than that before treatment,and the experimental group was better than the control group.(4)On the score of single symptom: except that the score of the control group with symptoms of eating less and taking abstaining did not decrease significantly before and after treatment(P>0.05),the scores of all symptoms in the two groups decreased compared with those before treatment(P <0.05),indicating that the symptoms were improved compared with those before treatment.Comparison between groups,urinary frequency,urgency,urine pain,labor that is sent,lumbar debility,body tired fatigue,less food,stay,thirsty symptom score difference was statistically significant(P < 0.05),the test group in frequency,urgency,urine pain,labor that is sent,lumbar debility,body tired fatigue,less food,stay,dry mouth symptoms improved better than that in control group.(5)in terms of laboratory indexes,the white blood cell count was improved compared with that in the group(P< 0.05),and the treatment group was superior to the control group(P < 0.05).After2-mg treatment,there was some improvement(P < 0.05),and the treatment group was better than the control group(P < 0.05).After treatment,the bacteria culture in the middle part of the two groups had obvious negative transformation,and the negative transformation rate of the experimental group was higher than that of the control group.(6)safety evaluation: no significant adverse events were observed in the two groups during the observation period,indicating the safety of clinical application of zishenshenqidihuang decoction in the treatment of chronic urinary tract infection with deficiency of qi and Yin and dampness-heat.Conclusion: zishenshenqidihuang decoction can effectively improve the clinical symptoms of patients,especially in the frequency of urination,urination urgency,urinal pain,get sick from fatigue symptom's improvement is better than the control group,it can also effectively reduce the white blood cell in the urine,and urine bacterial colonies,disease efficacy is better than the control group,and has good safety.The results showed that zishenshenqidihuang decoction was an effective prescription for the treatment of chronic urinary tract infection with deficiency of qi and Yin and dampness-heat. |
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