The Clinical Effect Of Ling Shu Tianma Decoction On H-type Hypertension And Its Effect On Hypersensitive C-reactive Protein And Interleukin-6

Purpose Observe the clinical effect of Ling Zhu Tianma Decoction on H-type hypertension patients with phlegm-dampness-obstructed accumulation,and observe the changes of serum hypersensitive C-reactive protein and Interleukin-6 in h-type hypertension patients with phlegm-dampness-obstructed accumulation,so as to explore the possible mechanism of Ling Zhu Tianma Decoction on H-type hypertension.Methods Sixty patients with H-type hypertension with excessive phlegm-dampness were randomly divided into control group and treatment group,30 cases each.The control group adopted the antihypertensive regimen recommended by the ninth edition of internal medicine,and the treatment group added ling shu tianma decoction on the basis of the treatment in the control group.one dose per day,two times in the morning and evening,followed by warm treatment after meals.The observation period was four weeks.Statistics and analysis Changes of blood pressure,Blood pressure variation,Hcy level,TCM syndrome score,hypersensitive c-reactive protein and interleukin-6 in the two groups.Results 1.Curative effect index:(1)Blood pressure levels:after treatment,24-hour average systolic and diastolic blood pressure in both groups were significantly decreased(P<0.01),The treatment group was superior to the control group in terms of blood pressure reduction the overall response rate was 93.32% in the treatment group(23 effective,5 effective and 2 ineffective),and 90.00% in the control group(13 effective,14 effective and 3 ineffective).The treatment group was superior to the control group in terms of Antihypertensive effects(P < 0.05).(2)Blood pressure variation:After treatment,the standard deviation of systolic blood pressure at 24 h in the treatment group,the standard deviation of diastolic blood pressure at 24 h in the control group and the standard deviation of systolic blood pressure at 24 h in the control group were significantly reduced(P<0.05),while the standard deviation of diastolic blood pressure at 24 h in the control group was not significantly reduced(P>0.05),After treatment,The treatment group was superior to the control group in blood pressure standard deviation(P<0.05).(3)TCM syndrome score:after treatment,the score of TCM symptoms in the control group was significantly lower than that before treatment(P<0.05),the score of TCM symptoms in the treatment group was significantly lower than that before treatment(P<0.01),and the improvement of TCM syndrome score in the treatment group was significantly better than that in the control group(P<0.01).(4)TCM syndrome efficacy:the total effective rate was 93.33% in the treatment group of 7 patients with obvious effects,21 patients with effective effects and 2 patients with ineffective effects,and the total effective rate was 50.00% in the control group of 1 patient with obvious effects,14 patients with effective effects and 15 patients with ineffective effects.The curative effect of TCM syndrome in the treatment group was better than that in the control group(P<0.01).(5)Hcy level:After treatment,the level of Hcy in the treatment group was significantly lower than that before treatment(P<0.01),while the level of Hcy in the control group was not significantly lower than that before treatment(P >0.05),and the level of Hcy in the treatment group was significantly lower than that in the control group(P<0.01).2.Inflammatory indicators:(1)Hypersensitive c-reactive protein:after treatment,both groups could reduce serum hypersensitive c-reactive protein(P<0.05),and the treatment group was better able to reduce the level of serum hypersensitive c-reactive protein(P<0.05).(2)Interleukin-6:after treatment,both groups could reduce serum interleukin-6(P<0.05),and the treatment group was better able to reduce the level of serum interleukin-6.Conclusion(1)Ling Shu Tianma decoction can reduce blood pressure,improve the degree of variation in blood pressure.(2)Ling Shu Tianma decoction can reduce the score of TCM syndrome,so as to improve the clinical symptoms;(3)Ling Shu Tianma decoction can reduce the level of blood Hcy,at the same time can reduce the level of inflammation indicators hs-crp and il-6 and reduce the inflammatory response,which may also be the mechanism of treating h-type hypertension with lingshu gastrodia elata decoction.