Clinical Observation On Sangqinzhike Recipe In Treating Acute Exacerbation Of Chronic Obstructive Pulmonary Disease With Syndrome Of Phlegm Heat Obstructing Lung

Objective:Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is one of the important reasons for the rapid deterioration of patients with chronic obstructive pulmonary disease(COPD),and it is also the main cause of death of COPD patients.AECOPD hospitalized patients,the conventional treatment course is longer,the effect is not good.The experimental trial of Sangqinzhike Recipe in the early treatment of AECOPD with syndrome of phlegm heat obstructing lung has significant effect.The purpose of this study was to observe the clinical efficacy of Sangqinzhike Recipe in the treatment of AECOPD with phlegm-heat,sputum and lung syndrome,explore the clinical advantages of Sangqinzhike Recipe in patients with AECOPD phlegn heat obstructing lung and lay the foundation for further clinical promotion and effect mechanism research.Methods:This study used a randomized controlled trial study design.Subjects were selected to meet the inclusion criteria.From May 2019 to January 2020,80 patients were admitted to the hospital for AECOPD(75 patients completed the study and 5 patients fell off).The subjects were randomly assigned to the experimental group and the control group at a ratio of l:1.The Sangqinzhike Recipe combined with the conventional western medicine treatment group was set as the experimental group,37 eases were completed and 3 eases were dropped off.As a control group,38 cases were completed and 2 cases were lost.Both groups received conventional basic treatment.Patients were given continuous low-flow oxygen inhalation,anti-inflammatory,bronchiectasis,antispasmodic and asthmatic,assisted sputum excretion,improved ventilatory function,and empirical anti-infective treatment to maintain water-electrolyte acid-base balance while collecting patients The sputum specimens were subjected to sputum culture+drug sensitivity test.In the basic treatment,the experimental group was given Sangqinzhike Recipe,the contracting party of the hospital,25ml each time,twice a day,and the course of treatment was 7 days.The control group received only basic treatment for 7 days.Patients in both groups were followed up to discharge after the course of treatment.Fill in the TCM Syndrome Scale and the COPD ssessment Test(CAT)to quantify the degree of symptoms,and measure the levels of serum procalcitonin(PCT)and C-reactive protein(CRP)to assess infection and Inflammation intensity.Check the percentage of forced expiratory volume in one second/forced vital capacity(FEV1/FVC%)and the percentage of predicted vital force(Forced vital capacity,FVC%)in the first second.Assess pulmonary ventilation.Collect TCM symptoms scores,total points,CAT scores,PCT,CRP and other indicators before treatment and on the 3rd day of treatment.The detection time points are before treatment,3rd day of treatment,7th day of treatment,and before discharge;Functional indicators FEV1/FVC%,FVC%,testing time is 7 days before treatment,before discharge;record length of hospitalization;collect safety indicators such as body temperature,pulse,heartbeat,blood,urine,stool routine,liver and kidney function,test time points Before treatment,on day 7 and before discharge.SPSS 21.0 software was used to analyze the differences between the two groups of data and compare the clinical efficacy between the two groups.Results:(1)There were no statistical differences in the age,gender,TCM symptom scores,individual scores,CAT scores,CRP and PCT of the two groups of subjects before treatment(P>0.05),which were comparable.(2)At the end of the treatment period,the total effective rate in the test group(91.9%)was significantly higher than that in the control group(65.8%)(P<0.05).The TCM symptom score,individual scores,CAT score,FVC%,CRP and PCT in the experimental group were significantly better than those in the control group(P<0.05).There was no statistical difference in FEV1IFVC%between the two groups(P>0.05).(3)Before discharge,the test group had better cough,expectoration,shortness of breath,and TCM symptom scores than the control group.The differences between the groups were statistically significant(P<0.05),and the chest tightness scores between the two groups were not statistically significant(P>0.05).There was no significant difference in CRP and PCT between the two groups(P>0.05).(4)The length of stay in the test group was significantly shorter than that in the control group(P<0.05).(5)During the hospitalization period,the vital signs such as body temperature,Pulse,and heartbeat were stable,and laboratory indicators such as blood,urine,stool routine,and liver and kidney function were not significantly abnormal.Con:clusion:Sangqinzhike Recipe is effective in treating AECOPD with syndrome of phlegn heat obstructing lung has high safety.It can effectively improve the respiratory symptoms such as cough,sputum and dyspnea,and the effect on the main symptoms of sputum is significantly better than that of westerm medicine alone;it can quickly control infection It can effectively reduce the level of inflammatory response,help patients to restore their lung ventilation fimction faster,and can significantly shorten the number of days of hospitalization for patients.