The Case-Control Study On Risk Factor Of Knee Osteoarthritis

Objectives:To explore are there any potential risk factors of knee osteoarthritis(KOA)through case-control study by comparing general clinical data,personal history,previous history,blood biochemical test,etc,between case group and control group.To provide bases for KOA's health education,prevention,treatment and prognosis and clues for its etiology research and consequently contribute to reduce the incidence and disability of KOA,save medical resources,reduce the economic burden of patients,and improve the quality of life.Methods:Including KOA patients and trauma patients respectively admitted to the Department of Orthopaedics and Rheumatology and Immunology and the Department of Emergency and Orthopedics of the Second Affiliated Hospital of Kunming Medical University from January 2014 to January 2019 as case group and control group.The control group were all identified to exclude osteoarthritis by imaging examination.The control group was matched with the case group members in terms of age and gender in order to reduce the interference of age and gender factors.Collect the general clinical data,personal history,previous history,and blood biochemical test of the two groups.Statistical analysis was performed using SPSS 23.0 software package.The measurement data were expressed as mean ±standard deviation.Using Student's t test for comparison between the two groups.Using chi-square test for comparison between the counting data groups and Fisher's exact probability method when the theoretical frequency is too low.Using Logistic multivariate regression analysis for analysis of independent risk factors of the risk factors screening from the statistics.P<0.05 was considered that the difference was statistically significant.Results:1.Statistically significant factors include gender,age,occupation,history of smoking,history of driking,body mass index(BMI),history of hypertension,history of hyperlipidemia,history of hyperuricemia,history of osteoporosis,other immune system diseases,triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),blood glucose(GLU).2.Independent risk factors include female(OR=3.312,95%CI:2.073-7.209),51 years old-60 years old(OR=4.409,95%CI:2.052-17.732),61-70 years old(OR=5.118,95%CI:2.556-10.251),71 years old-80 years old(OR=6.367,95%CI,4.929-21.806),than 80 years old(OR=4.292,95%CI:1.780-10.348),occupation(heavy Physical labor)(OR=2.446,95%CI:1.468-3.384),BMI>24(OR=1.860,95%CI:2.237-5.473),and history of osteoporosis(OR=2.784,95%CI:1.041-8.024),and associated with other immune system diseases(OR=3.674,95%CI:2.866-21.009).history of hyperlipidemia(OR=2.069,95%CI:1.486-11.836).3.There was no significant difference in nationality and history of allergy between thecase group and control group(P>0.05).Conclusions:1.New risk factors for KOA disease was discovered:accompanied with other immune system diseases.2.This study suggest that the risk factors for hyperglycemia and osteoporosis history,which were controversial,are independent risk factors for KOA disease.3.The results remained in this study are basically consistent with the past in addition to factors such as nationality and allergy history.