Risk Factors Analysis Of Knee Osteoarthritis In Middle-aged And Senior Residents In Tianhe District Of Guangzhou

Objective:To take an epidemiological investigation about the situation of kneeosteoarthritis(KOA) in Tianhe District in Guangzhou, and to analyze its prevalence rate,age and gender distribution. Then, through the Logistic regression analysis, toidentify risk factors of KOA and to add some useful research data for Guangzhou, oreven for China. At last, to find a way that can prevent KOA early, cure it scientificallyand decrease the incidence efficiently.Methods:The study investigated360respondents and adopted1:1matched case-controldesign, basing on hospital and matching with age. It started from April2011toFebruary2012in the first affiliated hospital of Jinan University(Guangzhou overseasChinese hospital, located in Tianhe District). And the respondents were all patitents inthis hospital. An unified questionnaire was designed to collect information, and SPSS13.0software was adopted to take single conditional logistic analysis for screeningvariables and discussing the impacts of probable risk factors. Then, the multivariateconditional logistic regression analysis was employed to screen risk factors further.Results:Among the elderly population in Tianhe District of Guangzhou, the results ofunivariate analyzes show that, gender, body mass index, education level, occupation,history of knee surgery, diabetes, hypertension, osteoporosis, eating seafood, smoking,climbing stairs often, swimming, climbing mountain, tai chi, family history are relatedto KOA. And the results of multi-factor analysis show that, KOA is associated with sex,BMI, history of knee surgery, diabetes, eating seafood, smoking, climbing stairs often,swimming, climbing mountain and family history. What’s more, eating seafood andswimming are the protection factors of KOA; while female, BMI, history of kneesurgery, diabetes, smoking, climbing stairs often, climbing mountain and family historyare the risk factors. Conclusions:(1) The questionnaire designed by us, called bone and joint health survey, shows ahigh reliability, which can be used for a wide range of investigation further and is worthpromoting and popularizing.(2) There is a significant positive correlation between age and radiologicalclassification. In the company of age increasing, the imaging performance of KOA is onthe increasing, and K/L grade Ⅱ, grade Ⅲ and Ⅳ are growing significantly. What’smore, K/L grade Ⅱ in all age segment are high, K/L grade Ⅲ is at the highest ratebetween70to79years old, while is decreasing in segment which is more than80years.(3) In the control of potential confounding factors, among the elderly population inTianhe District of Guangzhou, the results show that, KOA is associated with sex, BMI,history of knee surgery, diabetes, eating seafood, smoking, climbing stairs often,swimming, climbing mountain and family history. What’s more, eating seafood andswimming are the protection factors of KOA; while female, BMI, history of kneesurgery, diabetes, smoking, climbing stairs often, climbing mountain and family historyare the risk factors. Consequently, in the process of preventing and curing KOA, weshould encourage the high-risk groups or KOA patients to eat more seafood, take moreswimming, while avoid other risk factors.