Clinical Observation Of Dingkundan In The Treatment Of Chronic Obstructive Pulmonary Disease With Stagnancy Of Both Blood And Qi In Stable Stage

Background:Chronic obstructive pulmonary disease(COPD)is a chronic disease that seriously affects human health.It is clinically characterized by cough,sputum and irreversible airflow limitation.Due to the continuous increase in environmental pollution and the number of smokers,the prevalence of COPD is increasing year by year.COPD will become the third leading cause of death in the world in the next ten years,which brings a heavy economic burden and medical care to patients and society Consumption of resources.At present,traditional western medicine can only improve the symptoms of COPD,and there is no effective medicine that can effectively alleviate the decline of patients'lung function.Traditional Chinese medicine has a long history of treating chronic obstructive pulmonary disease.In the Ming Dynasty," Shou Shi Bao Yuan�Phlegm Asthma" stated:The cold turns to heat,and phlegm and asthma will occur,and the lungs will be full of sputum,and the lungs will be full of asthma.Threatening incitement,sinking into a pit.Both noses twitched,coughing,thirsty,and snoring,and proposed to use Dingchuan Decoction to treatshortness of breath.Guang Yuyuan Ding Kundan,born in the Ming Dynasty,has long been used as a health and disease prevention drug for the treatment of a variety of chronic diseases.It has the effects of nourishing qi and blood,regulating menstruation and depression,and qi stagnation and blood stasis are important pathological mechanisms of COPD in the stable period.One.Therefore,the use of Ding Kundan for the treatment of COPD can be differentiated,which can provide more treatment options for this disease,and take advantage of the traditional Chinese medicine.Objective:After using Guangyuyuan Ding Kundan to treat patients with chronic obstructive pulmonary qi stagnation and blood stasis type for 12 weeks,observe the patients'FS-14 score,6MWD,CAT score,mMRC score,SAS score,SDS score and pulmonary function(FEV1,FVC,FEV1/FVC),to explore the effects of Ding Kundan on the fatigue,mobility,clinical symptoms,psychological status and pulmonary function of patients with chronic obstructive pulmonary qi stagnation and blood stasis in the stable phase.To provide more clinical options for the treatment of COPD with traditional Chinese medicine.Research methods:1 Research designA randomized controlled clinical design method was adopted.A total of 60 subjects who were diagnosed with chronic obstructive pulmonary qi stagnation and blood stasis during the stable period in the respiratory department and inpatient department of our hospital from June 2019 to December 2019 were selected.The experimental group There were 30 cases and 30 cases in the control group.Based on the traditional Chinese medicine lung rehabilitation training,the experimental group was given Ding Kundan,and the control group was given Ding Kundan starch mimic.Traditional Chinese medicine lung rehabilitation training is conducted in a professional venue under the guidance of a full-time coach.Each subject performs exercises of Liu Zi Jue,Baduan Jin,Tai Chi,and Wu Qin Xi.Train 60 times 3 times a week.The method of taking Ding Kundan or simulant is twice a day,one bottle at a time,and warm water 30 minutes before breakfast and dinner.Interventions totaled 12 weeks.The changes of FS-14 score,6MWD,CAT score,mMRC score,SAS score,SDS score and pulmonary function(FEV1,FVC,FEV1/FVC)before and after intervention were observed.2 Course of treatmentThe entire test cycle lasted 12 weeks.3 Observation indicatorsObservation indicators include FS-14 score,6MWD,CAT score,mMRC score,SAS score,SDS score,and pulmonary function(FEV1,FVC,FEV1/FVC).Results:1.Fatigue score evaluation:After the test,the fatigue scores(FS-14)of the patients in the experimental group and the control group were significantly improved than before the test,with statistical significance(P<0.05);the fatigue of the experimental group was improved compared with the control group.More significantly,there was statistical significance between the two groups(P<0.05).2.Evaluation of mobility:After the test,the six-minute walking distance between the experimental group and the control group was significantly increased compared with before the test,and both were statistically significant(P<0.05);the experimental group was more increased than the control group in the six-minute walking distance.There were more,there was statistical significance between the two groups(P<0.05).3.Pulmonary function evaluation:After the test,FVC in the control group decreased compared to the previous(from 2.52�0.78 to 2.51�0.77);FV1,FEV1/FVC increased compared to the previous,but the difference was not statistically significant(P>0.05).After the test,the experimental group had more significant improvements in FEV1,FVC,FEV1/FVC than the control group,and the difference was statistically significant(P<0.05).4.Evaluation of clinical symptoms:After the test,the mMRC score and CAT score of patients in the experimental group and the control group were significantly lower than before the test(P<0.05).The mMRC score of the experimental group was significantly improved compared with the control group,and the difference was statistically significant(P<0.05);the CAT score of the experimental group was not significantly improved compared with the control group,and the difference was not statistically significant(P>0.05).5.Psychological evaluation:After the test,the SAS scores of patients in the experimental group and the control group were significantly lower than before the test(P<0.05).The SAS scores of the experimental group were more significant than those in the control group.The comparison between the two groups was statistically significant.(P<0.05).After the test,the SDS score of the control group had a downward trend compared with the previous one,but the difference was not statistically significant(P>0.05);the SDS score of the experimental group was significantly lower than the previous one,and the difference was statistically significant(P<0.05),and the experimental group The SDS score was more significant than the control group,and the difference was statistically significant(P<0.05).Conclusions:1.Ding Kundan can helps to improve the fatigue of patients with COPD and blood stasis(FS-14 score)in the stable phase.2.Ding Kundan can helps to improve the mobility of patients with COPD and blood stasis(6MWD).3.Ding Kundan can helps to improve the clinical symptoms(CAT score,mMRC score)of patients with chronic obstructive pulmonary qi stagnation and blood stasis.4.Ding Kundan can helps to improve the psychological status of patients with chronic obstructive pulmonary Qi stagnation and blood stasis(SAS score,SDS score).5.Ding Kundan can helps to improve the lung function and delay the decline of lung function in patients with chronic obstructive pulmonary qi stagnation and blood stasis(FEV 1,FVC,FEV 1/FVC).