The Observation On The Changes Of Intestinal Floraand Clinical Effect By Treating The Patients With Functional Constipation Types Of Qi Stagnation And Jin Deficiency Using Changrun Decoction

Objective: To observe the effect of intestinal flora by treating the patients with functional constipation types of Qi stagnation and Jin Deficiency,and evaluate the clinical efficacy of Changrun Decoction.Methods: In this study,72 patients with functional constipation of Qi stagnation and Jin Deficiency were enrolled and randomly divided into two groups,36 cases of treatment group and 36 cases of control group.The treatment group was adopted the Changrun Decoction,and the other group was treated with PEG 4000 for 4 weeks.To observe the changes of the numbers of intestinal flora,pH and proportion,constipation severity score(CSS),Qi stagnation and Jin deficiency symptom score.And the clinical curative effect of the Changrun Decoction was evaluted by statistical comparison and analysis.Result:1.Before treatment,the baseline data of the two groups were statistically significant(P>0.05).2.After treatment,the two groups improved in terms of microflora disorder,constipation severity score,the quantitative scores of Qi stagnation and Jin deficiency and symptom distribution.1)Changes in the intestinal flora numbers,bacilli proportion and pH value of intestinal flora:after the treatment,the numbers of Bifidobacterium,Lactobacillus,Bacteroid and bacilli proportion increased significantly in the two groups,and the numbers of Escherichia coli and pH value decreased significantly(P< 0.05);After treatment,the therapeutic effect of treatment group was better than that of control group in improving bacilli ratio,pH value,and the quantities of bifidobacterium and Escherichia coli(P< 0.05),and there was no difference between the two groups in improving the quantities of Lactobacillus,Escherichia coli and Bacteroid(P>0.05).2)CSS: after treatment,the constipation symptoms and the two groups' scores of CSS were significantly improved(P<0.05).after treatment,there were differences in improving of the frequency of defecation,fecal properties and total scores between the two groups,and the treatment group was superior to the control group;there was no difference in the improvement of the remaining symptoms.(P>0.05)3)The quantitative scores of Qi stagnation and Jin deficiency: after treatment,the improvement of tongue situation in the treatment group was not obvious(P> 0.05),and there were significant differences between the remaining symptoms and the total score(P<0.05).In the aspect of dry mouth who wants to drink and the situation of tongue and pulse,the control group had no significant improvement(P> 0.05).And in the remaining symptoms and the total score,the control group showed significant difference(P<0.05).After treatment,there were differences in dry mouth who wants to drink and total scores between the two groups,and the treatment group was superior to the control group(P<0.05);there was no difference in the improvement of the remaining symptoms.(P>0.05)Conclusion:1)Changrun Decoction treatment of functional constipation with the type of Qi stagnation and Jindeficiency has obviously asignificant short-term therapeutic effect,and there is no obvious adverse reaction.2)The two treatment methods can effectively improve intestinal dysbacteriosis,constipation clinical symptoms and syndrome of Qi stagnation and Jin Deficiency.And the curative effect of Changrun decoction is better than that of PEG 4000.3)In improving the numbers of Bifidobacterium,the numbers of Escherichia coli and pH value,defecation frequency,fecal properties,dry mouth,the curative effect of Changrun Decoction is better than PEG 4000.