Correlation Between Serum Uric Acid Level And EGFR In Middle-aged And Elderly People

Background:Uric acid is the end product of sprine metabolism in the body and is mainly excreted by the kidney.Hyperuricemia is closely related to Chronic kidney disease?CKD?,which can aggravate the progression of kidney disease and is a risk factor for the occurrence and development of CKD.With the development of social economy,the improvement of living standards and the changes in diet structure and habits,the prevalence of hyperuricemia in China has increased year by year.This study used a cross-sectional study to analyze the relationship between serum uric acid level and estimated glomerular filtration rate?eGFR?in middle-aged and elderly populations.The purpose of this study is to evaluate the effect of serum uric acid level on renal function in middle-aged and elderly population.Methods:A total of 2475 people aged 40 years or older were enrolled in this study who were checkup in our hospital.They were divided into normal serum uric acid group and hyperuricemia according to Chinese multi-disciplinary consensus on the diagnosis and treatment of hyperuricemia and its related diseases 2017 definition of hyperuricemia.The baseline characteristics between groups were compared,respectively.?2 test was used to analyze the prevalence of eGFR<90ml·min^-1·?1.73m²?^-11 in different age groups.Pearson correlation and partial correlation were presented to explore the relationship between serum uric acid level and clinical variables as well as eGFR.Logistical regression models were used to evaluate the effect of hyperuricemia on presence of eGFR<90 ml·min^-1·?1.73m²?^-1.Results:1.The levels of urea nitrogen and serum creatinine in the hyperuricemia group were significantly higher than those in the normal serum uric acid group?P<0.001?,and eGFR was significantly lower than that in the normal serum uric acid group[male:91.00±22.51 vs 105.98±18.64 ml·min^-1·?1.73m²?^-1,female:114.77±28.60 vs151.95±26.35 ml·min^-1·?1.73m²?^-1,P<0.001].2.Aged 40-49,50-59,60-69 and?70,the proportion of eGFR<90ml·min^-1·?1.73m²?^-1in the hyperuricemia group was significantly higher than that in the normal serum uric acid group in both male and female populations?P<0.001?.3.Serum uric acid level was positively correlated with age?male:r=0.187,female:r=0.353,P<0.001?,after adjusting for age,serum uric acid were positively correlated with BMI,triglycerides,serum creatinine,blood urea nitrogen,and negatively associated with eGFR?male:r=-0.388,P<0.001,female:r=-0.509,P<0.001?.4.The risk of eGFR below 90 ml·min^-1?1.73m²?^-11 was significantly increased in the hyperuricemia population compare to the normal serum uric acid people?OR=4.249,95%CI=3.188-5.661,P<0.001?.Conclusion:Serum uric acid level is negatively correlated with eGFR in the aged 40and over elderly and hyperuricemia is an independent risk factor for renal dysfunction.