Correlation Analysis Between Baseline Serum Uric Acid Level With Impaired Fasting Glucose And Diabetes In Middle-aged And Elderly People

Objective:To explore the correlation between baseline serum uric acid(SUA)levels with impaired fasting blood glucose(IFG)and diabetes in middle-aged and elderly people.Methods:This study is based on the 2011 baseline and 2015 follow-up data of the China Health and Elderly Care Tracking Survey(CHARLS),and middle-aged and elderly people aged 45 and above are selected as the research objects.Groups were grouped according to baseline SUA levels,the epidemiological characteristics of SUA levels were analyzed,and the risk factors for impaired fasting blood glucose and diabetes between different SUA levels were analyzed.Linear regression modeling was used to evaluate the correlation between fasting blood glucose levels,and various risk factors for impaired fasting blood glucose and diabetes.Based on the results of follow-up data in 2015,the subjects were divided into normal blood glucose group,impaired fasting blood glucose group,and diabetes group.A single factor analysis of the risk factors of diabetes and impaired fasting blood glucose was carried out,and multivariate logistic regression analysis was used to explore the relationship between serum uric acid and impaired fasting glucose and diabetes after adjusting for confounding variables.The study subjects were stratified according to age,and the relationship between serum uric acid levels in each age group,impaired fasting blood glucose and the onset of diabetes was analyzed.The ROC curve was used to evaluate the predictive value of serum uric acid levels on impaired fasting blood glucose and diabetes.Result:(1)The basic characteristics of baseline serum uric acid quartiles: the level of HDL-C increased with serum uric acid level.The quartiles of BMI,waist circumference,systolic blood pressure,diastolic blood pressure,TC,TG,LDL-C,and FPG levels were increased with elevated serum uric acid leve.(2)During the 4-year follow-up,a total of 467 subjects developed impaired fasting blood glucose and diabetes,with a cumulative incidence of 12.7%,of which 209 and 258 were impaired fasting glucose and diabetes,respectively,with a cumulative incidence of 5.67% and 7.0%,respectively.The results of comparison between the three groups of normal blood glucose,impaired fasting blood glucose and diabetes showed: there were statistically significant differences in the age,different regions,TC,TG,HDL-C,LDL-C,serum uric acid,systolic blood pressure,diastolic blood pressure,BMI,waist circumference(P<0.05),and there was no statistically significant difference in gender,educational background,smoking or drinking alcohol(P>0.05).(3)A univariate analysis of impaired fasting blood glucose showed that the levels of TG,serum uric acid,systolic blood pressure,diastolic blood pressure and waist circumference in the impaired fasting blood glucose group were higher than those in the normal blood glucose group(P<0.05),however there were no significant difference in the age,TC,HDL-C,LDL-C,BMI,gender,education background,smoking,drinking alcohol between the normal blood glucose group and the impaired fasting blood glucose group(P>0.05).Diabetes univariate analysis showed that patients in the diabetes group were older than those in the non-diabetic group,and TC,TG,LDL-C,systolic blood pressure,diastolic blood pressure,BMI and waist circumference were higher than those in the non-diabetic group(P<0.05),and the levels of HDL-C in the diabetes group was lower than that of the non-diabetic group(P<0.05),but there were no statistically significant difference in different regions,gender,education background,serum uric acid,smoking and alcohol consumption between the non-diabetic group and the diabetes group(P>0.05).(4)Fasting blood glucose levels are positively correlated with serum uric acid,systolic blood pressure,waist circumference,and age(P<0.05),but have no correlation with gender,LDL-C,HDL-C,TC,TG,diastolic blood pressure,BMI,smoking and drinking(P>0.05).(5)The results of multivariate logistic regression analysis showed that after other confounding factors being adjusted,the baseline serum uric acid level was a risk factor of impaired fasting blood glucose(OR=3.848,95%Cl=3.343-4.43,P<0.001).There was no correlation between the onset of diabetes and the baseline serum uric acid level(OR=0.99,95%Cl=0.887-1.105,P=0.862).In the age subgroup analysis,baseline serum uric acid was correlated with the incidence of impaired fasting blood glucose.(6)Serum uric acid has a good predictive value for the risk of impaired fasting blood glucose.AUC of SUA was=0.8781,the sensitivity of 76.56% and the specificity of 91.15% with the best cut-off value 5.55mg/dl.In the age sub-group,serum uric acid has a good predictive value for the occurrence of impaired fasting blood glucose,and serum uric acid predicts the occurrence of impaired fasting blood glucose better than waist circumference,systolic blood pressure,and BMI.Serum uric acid is not a good predictor of diabetes.Conclusion:(1)In middle-aged and elderly people aged 45 and above,serum uric acid is associated with the risk of impaired fasting blood glucose,and serum uric acid may be a risk factor for the risk of impaired fasting blood glucose,but there is no correlation between serum uric acid and the risk of diabetes,which suggests that serum uric acid can be used as a potential indicator for the prevention of impaired fasting blood glucose.(2)Fasting blood glucose level is positively correlated with blood uric acid in the overall study population.(3)Baseline serum uric acid has a good predictive value for impaired fasting blood glucose,and serum uric acid is superior to waist circumference,systolic blood pressure,BMI,and serum uric acid has no obvious reference value for the diagnosis of diabetes.