Explore Chronic Kidney Disease Patients With Serum Uric Acid Level And ADMA, EGFR Relationship To Differences Of Gender

Object:To explore serum uric acid levels (UA)，Asymmetric Dimethylarginine (ADMA),estimated glomerular filtration rate (eGFR) between their relationship and genderdifferences in non-diebetes CKD stage1-4patients. For clinical gender-specific usingdifferent strength decrease the serum uric acid level to retard the progression of kidneydisease, reduce cardiovascular events provide a basis.Method:In a cross-sectional study,245non-diebetes CKD stage1-4patients (125femal and120male) were investigated. We collected data including serum urea, serum creatinine, serumuric acid, etc. Patient’s serum ADMA were determined by Enzyme Linked ImmunoabsordentAssay. Through the analysis of the linear regression of serum uric acid, ADMA, estimatedglomeruloner filtration rate (eGFR) relationship and gender difference. Further subgroupanalysis was performed between male and female in smoker group and non-smoker group.Result:(1) In non-diebetes CKD stage1-4patients, serum uric acid was negative correlated witheGFR in both men (R=-0.293，P=0.001) and women (R=-0.383，P＜0.001). In non-diebetesand non-smoker CKD stage1-4patients, serum uric acid was negative correlated with eGFRin both men (R=-0.356, P=0.004) and women (R=-0.383, P＜0.001).In addition to age andserum creatinine, stepwise multiple factors regression analysis of different gender influencefactors of female patients with eGFR, which factors affect eGFR including serum uric acid,systolic blood pressure (R=0.428), the male influence factors including hemoglobin, uricacid, weight, total triglyceride (R=0.617), The coefficient of serum uric acid in linear regression (0.109) or stepwise regression model (0.097) in female is bigger than that in men(0.072,0.06). It was indicating serum uric acid influencing eGFR more significant in wementhan in men.(2) In non-diebetes CKD stage1-4patients, eGFR was negative correlated with ADMA inboth men(R=-0.239，P=0.014) and women (R=-0.307，P=0.001).In non-diebetes and non-smoker CKD stage1-4patients, eGFR and ADMA in femalepatients with negatively correlated (R=-0.307，P=0.001), in male patients, there was nocorrelation (R=0.126，P=0.362).(3) In non-diebetes CKD stage1-4patients, serum uric acid was negative correlated withADMA in women patients (R=0.327，P=0.001) but there was no correlation in men(R=0.089，P=0.371).In non-diebetes and non-smoker CKD stage1-4patients, serum uric acid was negativecorrelated with ADMA in women (R=0.327，P=0.001). but there was no correlation in men(R=0.045，P=0.772).Conclusion:(1) In non-diebetes CKD stage1-4patients, serum uric acid was negative correlated witheGFR in women stronger than in men. Through the stepwise multiple factors regressionanalysis of different gender factors affect eGFR, suggestive of different gender uric acidlevels on eGFR effects of contribution degree may be different, and the female high uric acidlevels on the impact of eGFR than men, men and women may have different mechanisms.(2) In non-diebetes CKD stage1-4patients, eGFR was negative correlated with ADMA inboth men and women. However, in non-diebetes and non-smoker CKD stage1-4patients,eGFR was negative correlated with ADMA in women, but there was no correlation in men. Itindicated smoke was one of the important factors which influenced the corelationshipbetween eGFR and ADMA.(3) In non-diebetes CKD stage1-4patients, serum uric acid was negative correlated with ADMA in women but there was no correlation in men. Our results indicate that may be ofserum uric acid in different gender on glomerular endothelial function by differentmechanisms, so as to clinical gender-specific, at different times may need to use differentstrength decrease serum uric acid levels to retard the progression of kidney disease, reducecardiovascular events and provide a theoretical basis...