Clinical Characteristics And Maternal And Fetus Outcomes Of Gestational Diabetes Mellitus Complicated With Hypertensive Disorders Complicating Pregnancy

Objectives To analyze the clinical characteristics and maternal and fetus outcome s of patients with gestational diabetes mellitus complicated with hypertensive disor ders complicating pregnancy.Methods 3196 pregnant women who delivered in Hebei General Hospital from S eptember 2016 to October 2018 were recruited in the study,which included 3 gro ups:2646 cases in the normal group,480 cases in the GDM group,and 70 cases in the GDM+HDCP disease group.Age,body mass index?BMI?before pregnanc y,blood glucose?FPG?,OGTT?0h,1h,2h?,blood lipid level and maternal and i nfant complications were recorded in the three groups;The correlation of risk fac tors with GDM group and GDM+HDCP disease group were analyzed.Results?1?Compared with the normal group,the age,BMI before pregnancy,blood glucose?FPG?and TG levels in the GDM group were higher,while the TC,HDL-c levels and the ratio of primipara were lowerly with statistically signi ficant differences?P<0.05?.Logistic univariate and multivariate regression analysis of the above related factors showed that:Age 30?34 years old?OR=1.504,95%C I:1.161?1.949?,age>35 years old?OR=2.342,95%CI:1.735?3.160?,pre-pr egnancy BMI?24kg/m²?OR=1.946,95%CI:1.578?2.399?,early pregnancy FPG?5.1mmol/L?OR=2.850,95%CI:2.198?3.695?,TG level>4.73mmol/L?OR=1.543,95%CI:1.049².271?and primary maternal?OR=1.273,95%CI:1.005?1.613?are risk factors for GDM,while age<25 years old?OR=0.442,95%CI:0.250?0.783?is the protective factor for GDM,logistic regression models:P_GDM=1/{1+exp[-?-2.561+0.408×Age 30?34 years old+0.851×Age?35 years old+0.666×pre-pregnancy BMI?24kg/m²+1.047×early pregnancy FPG?5.1mmol/L+0.434×TG leve l>4.73mmol/L+0.241×primary maternal?].?2?Compared with the GDM group,the pre-pregnancy BMI,blood glucose?FPG?,TG,VLDL-c levels and the ratio of p rimipara in the GDM+HDCP disease group were higher,while the HDL-c levels were lower with statistically significant differences?P<0.05?.Logistic univariate a nd multivariate regression analysis showed that:Pre-pregnancy BMI?24kg/m²?OR=4.463,95%CI:2.468-8.070?and primipara?OR=1.876,95%CI:1.108-3.175?are risk f actors for GDM+HDCP.logistic regression models:PGDM+HDCP disease=1/{1+ex p[-?-3.177+1.496×Pre-pregnancy BMI?24kg/m²+0.629×primipara?]?3?In maternal and infant outcomes,compared with the normal group,the risk of macrosomy and deli very mode?section?in GDM group was significantly increased?P<0.05?.Compa red with the GDM group,the incidence of polyhydramnios,premature infants,low-birth-weight infants,pediatrics and postpartum hemorrhage in the GDM+HDCP di sease group was higher?P<0.05?.Conclusions 1 Pre-pregnancy body mass index BMI?24kg/m²,primipara is a risk factor for GDM+HDCP disease.2 Patients with GDM+HDCP disease have signific antly increased maternal and fetus complications such as polyhydramnios,prematur e infants,low-birth-weight infants,pediatrics and postpartum hemorrhage.Figure1;Table10;Reference 160.