Clinical Analysis Of203Cases Of Hypertensive Disorders Complicating Pregnancy

Objective: Explore the predictors of pregnancy outcome of hypertensive disorderscomplicating pregnancy(HDCP)Methods:1. Retrospective analyze cases of inpatient childbirth between January2011andDecember2012in the Military General Hospital of Beijing Pla and confirm correlationfactors of HDCP.2. Analyze the onset gestational age， prolongation of gestation and theterminating gestational age of different types of HDCP.3. Analyze the relationship of the pregnancy complications of HDCP and theperinatal outcome.4.Analyze the relationship of the clinical laboratory indicators of HDCP and theperinatal outcome.Results：1. Carrying out a systematic prenatal physical examination compared with thosenot，the incidence of neonatal complications is much lowe（rP<0.01），the Apgar scoreat1minute，5minute and10minute are higher（P<0.01），the difference of the birthgestational age have significant difference（P<0.05）；The percentage of primipara is81.7%；The percentage of gravida with high blood pressure is14.3%；The percentageof gravida with high blood pressure family history is27.9%.2. The onset gestational age of patients in mild pre-eclampsia， in severpre-eclampsia，in chronic hypertension complicated with mild pre-eclampsia and inchronic hypertension complicated with sever pre-eclampsia have significant difference（P<0.01），the onset gestational age of the four groups are35.12±4.51w，32.48±4.41w，17.68±5.75w，22.58±8.68w；The prolongation of gestation of patients in mild pre-eclampsia， in sever pre-eclampsia，in chronic hypertension complicated with mild pre-eclampsia and inchronic hypertension complicated with sever pre-eclampsia have significant difference（P<0.01），the prolongation of gestation of the four groups are36.14±13.47days，27.86±11.92days，139.10±20.65days，88.59±22.07days；The terminating gestational age of patients in mild pre-eclampsia，in severpre-eclampsia，in chronic hypertension complicated with mild pre-eclampsia and inchronic hypertension complicated with sever pre-eclampsia have significant difference（P<0.01），the terminating gestational age of the four groups are38.05±2.13w，35.31±3.23w，37.88±1.50w，35.16±3.95w；3. There is an association between the neonatal complications and HDCPcomplicated FGR，placental abruption，hypoproteinemi（aP<0.01；P<0.01；P<0.01）.4. There is an association between the neonatal complications and the clinicallaboratory indicators such as lactate dehydrogenase，uric acid，gestational randomurine protein（P<0.01；P<0.01；P<0.05）.Conclusion:1. Systematic prenatal physical examination can obviously improve the perinataloutcome. Primipara,gravida with high blood pressure、gravida with high blood pressurefamily history should be paid more attention to.2.Patients in chronic hypertension complicated with mild pre-eclampsia have theearliest onset gestational age and the longest prolongation of gestation；patients in mildpre-eclampsia have the latest onset gestational age，while ones in sever pre-eclampsiahave the shortest prolongation of gestation. The result can be used to prognosis thehypertensive disorders complicating pregnancy and assess the evolution of disease andget a better pregnancy outcome.3. There is an association between the neonatal complications and thecomplications of HDCP，which can be used to choose the treatment and the timing toterminate pregnancy for a better pregnancy outcome.4. There is an association between the neonatal complications and the clinicallaboratory indicators such as lactate dehydrogenase，uric acid，gestational randomurine protein. The early monitoring of those clinical laboratory indicators can be used topredict HDCP and assess the treatment.