| Pregnancy associated with diabetes includes diabetes complicating pregnancy in which diabetes is diagnosed before pregnant and gestational diabetes mellitus also called GDM in which intolerance of glucose is diagnosed for the first time during the course of the pregnancy.In pregnancy associated with diabetes more than 80% are GDM.In recent years,its incidence rate takes on a ascending tendency. Our country's incidence rate was 2.9% in 1997.Women with diabetes complicating pregnancy and GDM all occur glycometabolism disorder.After pregnancy , because of insulin resistance increasing gradually and sensitivity of insulin descending,blood glucose concentration of pregnancy increases easily. If the reserve function of pancreatic island is not enough ,receptor quantity reduces or function degrades, pancreatic island can not secrete enough insulin for compensation.If so,GDM occurs.The change of blood sugar level increasing also increases the blood glucose control difficulty of diabetes complicating pregnancy woman,and causes serious hazardous on mother and neonatal.Foreign and national scholars paid More and more attention to pregnancy and pregnancy outcome of pregnancy associated with diabetes.Early diagnosis and early therapy already become one of the important measures for decreasing perinatal complications of mother and neonatal and elevating obstetrics qualitative.Object:To approach the relationship between pregnancy associated with diabetes and pregnancy outcome,analyze pregnancy outcome with different blood sugar level.Method:To select 109 cases of pregnancy associated with diabetes and 109 cases of pregnancy with normal blood sugar level. All pregnant women delivery in the First,the Second and the Third clinical hospital of Jilin University and Changchun Department of Obstetrics and Gynecolofy Hospital from January 1,2001 to December 31,2006.We devided all the cases into five groups.The control group 109 cases were classified in group A.The diabetes complicating pregnancy 29 cases were classified in group B.The gestational diabetes mellitus 80 cases were classified in group C. According to the blood sugar level,we divided group B into group B1(with well-controlled glucose)which had 16 cases and group B2(without well-controlled glucose)which had 13 cases, and divided group C into group C1 (with well-controlled glucose)which had 30 cases and group C2(without well-controlled glucose)which had 50 cases.In our study we compared the clinical data of all groups. The outcome among all groups were analyzed with statistical method.Results:1. The incidence of eld pregnant woman(age≥30) ,family history of diabetes,abnomal gestation and birth history and gravidity,parity in the group B was significantly higher than that of group A(p<0.05).The gestational weeks in the group B was significantly lower than that of group A(p<0.05).The incidence of eld pregnant woman(age≥30) ,family history of diabetes,abnomalgestation and birth history and gravidity in the group C was significantly higher than that of group A(p<0.05).The gestational weeks in the group C was significantly lower than that of group A(p<0.05).The incidence of abnomal gestation and birth history and gravidity in the group B was significantly higher than that of group C(p<0.05).The gestational weeks in the group B was significantly lower than that of group C(p < 0.05).2.The incidence of pregnancy-induced hypertension syndrome,polyhydramnios,infection, PROM,DKA and cesarean delivery rate in the group B and C was significantly higher than that of group A(p<0.05).The incidence of fetal macrosomia ,fetal death ,malformation,premature infant and neonatal asphyxia in the group B was significantly higher than that of group A(p<0.05).The incidence of fetal macrosomia , premature infant,fetal distress in uterus and neonatal asphyxia in the group C was significantly higher than that of group A(p<0.05).3.The rate of therapy in group B(100.0%) is significantly higher than that of in group (43.7%)(p < 0.05). The rate of well-controlled glucose in group B(51.2%) is significantly lower than that of in group (85.7%)(p<0.05).4. The incidence of pregnancy-induced hypertension syndrome,polyhydramnios, infection,PROM and DKA in the group B2 was significantly higher than that of group A(p<0.05).The polyhydramnios,infection and PROM in the group B2 was significantly higher than that of group B1(p<0.05).The incidence of PROM in the group C1 was significantly higher than that of group A(p<0.05).The incidence of pregnancy-induced hypertension syndrome, polyhydramnios,infection and DKA in the group C2 was significantly higher than that of group A(p < 0.05).The incidence of pregnancy-induced hypertension syndrome,infection and DKA in the group C2 was significantly higher than that of group C1(p<0.05).The incidence of pregnancy-induced hypertension syndrome in the group B1 was significantly higher than that of group C1(p<0.05).The incidence of fetal macrosomia ,fetal death ,malformation, premature infant and neonatal asphyxia in the group B2 was significantly higher than that of group A(p<0.05).The incidence of fetal macrosomia, malformation, premature infant and neonatal asphyxia in the group B2 was significantly higher than that of group B1(p < 0.05).The incidence of fetal macrosomia ,fetal death,premature infant,fetal distress in uterus and neonatal asphyxia in the group C2 was significantly higher than that of group A(p<0.05).The incidence of premature infant and fetal distress in uterus in the group C2 was significantly higher than that of group C1(p < 0.05).The incidence of fetal macrosomia, malformation, premature infant and neonatal asphyxia in the group B2 was significantly higher than that of group C2(p<0.05).Conclusion:1,Family history of diabetes,age,high gravidity and parity, abnomal gestation and birth history are high risk factors of pregnancy associated with diabetes.2,Diabetes complicating pregnancy and GDM can pose adverseeffects on pregnant women and neonatal.The hazardous of diabetes complicating pregnancy is more serious than that of GDM.3,Diabetes complicating pregnancy in which diabetes is diagnosed before pregnant can be diagnosed easily.It is difficult to be diagnosed for GDM.4,GDM which is diagnosed in time and managed standard can gain better therapeutic efficacy than diabetes complicating pregnancy, decrease maternal and fetal complications.5,Maternal blood glucose with ideal control can reduce maternal and fetal complications,improve pregnancy outcome.
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