Investigation Of Nasopharyngeal Mycoplasma Pneumoniae-DNA Copies And Clinical Characteristics In Childhood Mycoplasma Pneumoniae Pneumonia

Objective:To explore relationship between nasopharyngeal Mycoplasma Pneumoniae(MP)-DNA copies and clinical characteristics in Mycoplasma pneumoniae pneumonia(MPP)in children.Methods:A total of 294 hospitalized MPP children were enrolled retrospectively and grouped according to the levels of nasopharyngeal MP-DNA copies tested:low copy level group(≤10~3/ml,n=21),moderate copy level group(10~4-10~6/ml,n=156)and high copy level group(>10~6/ml,n=117).Clinical manifestations,laboratory results and image features of the three groups were compared.ROC curve was used to analyze the predictive value of MP-DNA copies in refractory mycoplasma pneumoniae pneumonia(RMPP).Results:Compared with low and moderate MP-DNA copies groups,high MP-DNA copies group had longer duration of fever,higher peak temperature and CRP level.The incidence of consolidation or atelectasis,pleural effusion,multiple extrapulmonary complications and RMPP were significantly higher in high MP-DNA copies group than those in low/moderate groups.ROC curve analysis showed AUC of the MP-DNA copies for the diagnosis of RMPP was 0.701.The best threshold value estimated was 4.83*10~6/ml,the diagnostic sensitivity and specificity was80.8%and 55.4%,respectively.Conclusion:There may be possitive correlation between nasopharyngeal MP-DNA copies and inflammation,pulmonary and extrapulmonary damage in MPP children.High MP-DNA copies may serve as a clinical indicator for earlier diagnosis of RMPP.