Analysis On Relevant Factors Of Hepatic Dysfunction In Children With Mycoplasma Pneumoniae Pneumonia

Objective:To investigate the relationship between the incidence of hepatic dysfunction and the age of children,the severity of the disease,and the application of macrolide antibiotics.Method:215 patients who were diagnosed as "M. pneumoniae pneumonia" in hospitalized children from 2010.02 to 2011.01 were enrolled. Venous blood was collected on admission to detect liver enzymes,215 children with the pneumonia that not infected by M. pneumoniae served as control group.Result:(1)The value of ALT and AST were significantly higher than that of contrast group in acute phase(P<0.01). The incidence of hepatic dysfunction was also higher than that of contrast group, and the difference was statistically significant (χ2=9.77, P<0.01).(2) The incidences of hepatic dysfunction in different age groups:<1y 28.89%, 1-3y 26.67%,>3yl3.64%. Hepatic dysfunction was more common in children of <3y than that of>3y, the difference was statistically significant ((χ2=6.59, P<0.05)(3) The values of ALT and AST were found to be associated with the severity of the disease. The incidence of hepatic dysfunction in severe MPP was significantly higher than that of mild MPP, the difference was statistically significant (χ2=17.78,P<0.01). (4) The longer macrolide antibiotics were applicated, the higher incidence of hepatic dysfunction would occur, the difference was statistically significant (χ2=6.04,P<0.05)(5)The value of liver enzymes declined in recovery phase, especially the value of ALT and AST, the difference was statistically significant(P<0.01,P<0.05).Conclusion:1 Hepatic dysfunction is more common in patients with MPP than non-MP-infected pneumonia.2 Infant, severe pneumonia and the application of macrolide antibiotics are the risk factors of hepatic dysfunction.3 Hepatic dysfunction in Children with MPP usually have good prognosis.