Correlation Between Polysomnography And Event-related Potentials P300 In Adolescents With Depression

objective: To explore the correlation between cognitive impairment and sleep disorders in adolescents with depression,and to analyze the interaction mechanism between cognitive impairment and sleep disorders.Methods: A total of 34 adolescent patients with clinically diagnosed mood disorder(depressive episodes)were assessed for clinical factors(including gender,age),Hamilton Depression Rating Scale(HAMD),event-related potential(ERPs)P300 latency and amplitude,and polysomnography at baseline.(PSG).In the same period,12 healthy adolescents were subjected to Hamilton Depression Scale(HAMD),event-related potential(ERPs)P300 latency and amplitude,and polysomnography(PSG).Data analysis was performed using IBM SPSS24.0 software using t test,X2 test,Pearson correlation analysis,and linear regression analysis.Results: 1.HAMD total score,sleep time,wakefulness after sleep,sleep efficiency,sleep latency,REM latency,duration of awake duration,duration of REM duration,duration of N2,percentage of N1 phase,P300 latency and P300 amplitude There was a statistically significant difference in the healthy control group,P<0.05.The number of awake,duration of N1,duration of N3,percentage of REM,percentage of N2,and percentage of N3 were not statistically significant compared with the control group,P>0.05.2.Subject P300 latency and amplitude were both.Correlation withtotal sleep time,wakefulness after sleep,sleep efficiency,duration of awake,duration of REM,and percentage of REM,P300 latency and P300 amplitude entered the regression equation with the HAMD total score.Conclusion: 1.Adolescents with depression have extensive cognitive impairment and sleep disorders;2.Adolescents with cognitive impairment and sleep disorders interact and correlate;3.P300 latency and amplitude and rapid eye movement REM Correlation.