| Objective:(1)To explore the changes of sleep process and structure in children with asthma,and the relationship between the degree of disease and sleep disorder.(2)To detect the cognitive function status of children with asthma,and to analyze the relationship between the degree of control of asthma and cognitive dysfunction.(3)To understand the relationship between sleep disorder and cognitive dysfunction in children with asthma.Methods: 50 children with asthma were chosen as the study subjects.All children with asthma were divided into the partially controlled group and the non-controlled group according to the lung function text and C-ACT.The SDSC evaluation was completed in all asthmatic children,and night sleep respiratory was monitored for 6 to 12 hours by means of the sleep respiratory monitoring system.Among them,35 cases completed the detection of the IVA-CPT and the D-N: CAS.Results:(1)The incidence of sleep disorder was 92%(46/50),which was more common in the non-controlled asthma group(P<0.05).The total scores of SDSC and the scores of 6 dimensions of sleep disorders in the non-controlled group were higher than those in the partially controlled asthma group(all P<0.05).The total sleep time of 50 children at night <9h accounted for 94%.The sleep time of the non-control asthma group was significantly reduced compared with that of thepartially controlled asthma group(P<0.05).(2)The total scores of SDSC,five dimensions of sleep disorders including disorders of initiating or maintaining sleep,sleep apnea disorder,sleep-wake transition disorders,disorders of excessive somnolence and sleep hyperhydrosis were negatively correlated with C-ACT scores in 50 children with asthma(all P<0.05).(3)All the 50 children had decreased sleep efficiency,increased number of sleep awakenings,increased obstructive breathing events,and the longest duration of obstructive breathing events,increased sleep apnea hypopnea index,increased fastest heart rate,and decreased blood oxygen value.The change in the non-controlled group was more significant than that in the basic control asthma group(all P<0.01).(4)The sleep efficiency,blood oxygen value were positively correlated with C-ACT scores(P<0.05).Obstructive respiratory events,AHI,the longest duration of obstructive respiratory events,the fastest pulse rate and the average pulse rate difference were negatively correlated with the C-ACT scores(P<0.05).(5)In the IVA-CPT,the abnormal rate of the FSCQ and the FSAQ in the non-control group were hihger than that in the partially controlled asthma group(all P<0.05).The most common form of cognitive dysfunction was ADHD mixed.(6)In the D-N: CAS,the PLAN,ATT,SIM,SUC and FS of all children were impaired to some extent,which the non-controlled group was more significant(P<0.05).(7)The parameters including FSCQ,FSAQ,PLAN,SIM,ATT,SUC and FS in 35 children with asthma were positively correlated with C-ACT scores(P<0.05).(8)The cognitive parameters of children with asthma were negatively correlated with SDSC scores,disorders of initiating or maintaining sleep,sleep-wake transition disorders,disorders of excessive somnolence and AHI(P<0.05).Cognitive indexes were positively correlated with sleep efficiency,average blood oxygen value and minimum blood oxygen(P<0.05).Conclusion:(1)There were more sleep disorder problems of process and structure in the asthmatic children,which were obvious in the non-controlled group.The severity of sleep disorder in children with asthma was were positively correlated with the degree of asthma control.(2)There was likely to be that the cognitive function of children with asthma was impaired to some extent,which the attention deficit was more significant,especially when the asthma was not controlled.The degree of cognitive dysfunction in children with asthma was positively correlated with the degree of asthma control.(3)There was likely to be a relevance of influence between the degree of sleep disorders in children with asthma and cognitive function. |
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