The Association Between Serum Uric Acid And Abnormalities Of Glycolipid Metabolism

BackgroundThe prevalence of hyperuricemia has been increasing sharply in recent years,reaching 8.4% in China.At the same time,diabetes mellitus and dyslipidemia are also prevailing.Epidemiology studies indicated that hyperuricemia was associated with several chronic non-communicable diseases,including dyslipidemia,diabetes,hypertension,ect.We aimed to investigate the relationship between uric acid level with abnormalities of glucose and lipid metabolism in community dwelling middle-aged and elderly Chinese.MethodsA total of 10,375 subjects aged?40 years in a community-dwelling population were enrolled by cluster sampling during March to August 2010 at baseline and were followed for incident diabetes and dyslipidemia from August 2014 to July 2015.All the participants completed a comprehensive survey that included a detailed questionnaire,anthropometric measurement,a standard 75-g oral glucose tolerance test(OGTT),and blood samples were collected to test glycemia and biochemical measurements.Participants were categorized according to gender-specific quartiles of serum uric acid levels.Hyperuricemia was defined as serum uric acid >420 ?mol/L in men and >360 ?mol/L in women.Logistic regression models were used to evaluate the associations between serum uric acid and prevalent risks in baseline survey.Relative-risk regression models were used to evaluate the associations between serum uric acid and incident risks in follow-up study.ResultsHyperuricemia is associated with the increased risk of prevalent and incident diabetes.Baseline survey indicated,among the total population(n= 10,335),after multivariate adjustment,participants in the first quartiles had 1.17 folds [Odds ratio(OR),1.17,95% confidence interval(95% CI1.04-1.38)] increased risk of prevalent diabetes compared with those in the fourth quartile of serum uric acid;further analysis indicated,participants with hyperuricemia had higher risk of prevalent diabetes,compared to those with normal serum uric acid levels(OR 1.34,95% CI 1.16-1.56).Follow-up study showed that,in the participants without diabetes at baseline(n= 5,965),after multi-variable adjustment,individuals with hyperuricemia had 36% increased risk of incident diabetes [RR(risk ratio)1.36,95% CI 1.06-1.73].The increasing risks of prevalent and incident dyslipidemia risk were also observed in individuals with hyperuricemia.Baseline survey indicated,among the total population(n= 10,357),after multivariate adjustment,participants with hyperuricemia had 93%(OR 1.93,95% CI 1.70-2.18)increased risk of prevalent dyslipidemia,compared to those without hyperuricemia.Follow-up study showed that,in participants with normal lipid profiles at baseline(n= 6,050),individuals with hyperuricemia had increased risk of incident dyslipidemia(RR 1.02,95% CI 1.001-1.06)and low HDL-C(RR 1.03,95% CI 1.003-1.06).ConclusionsIn the middle-aged and elderly Chinese adults,serum uric acid level is associated with abnormalities of glucose and lipid metabolism.Individuals with hyperuricemia have significant increased risk of prevalent and incident risk of diabetes and dyslipidemia.Moreover,serum uric acid level is an independent risk for incident diabetes and dyslipidemia.Better control of serum uric acid level should be encouraged to prevent diabetes and dyslipidemia.