Clinical Efficacy Of Ultrasound-guided Anhydrous Elthanol Vs Lauromacrogol Sclerotherapy In Treatment Of Larg Simple Hepatic Cysts

Objective: To compare the clinical efficacy and adverse reactions of anhydrous ethanol and polycinnamol injection in the treatment of large simple hepatic cysts.Methods: One hundred and twelve patients with simple hepatic cysts?8cm in diameter treated at our hospital from September 2009 to September 2016 were randomly divided into two groups to receive either anhydrous ethanol(group A,69 cases)or lauromacrogol treatment(group B,43 cases).Clinical efficacy and adverse reactions were compared in the two groups.The two groups was further divided into three subgroups each according to the size of the cyst: 8-12 cm,13-16 cm,and 17-20 cm.The incidence of adverse reactions and abnormal liver function were compared among different subgroups.Results: The total effective rate did not differ significantly between groups A and B(95.7% vs 95.4%,P>0.05).The cure rate of group B(67.4%)was significantly higher than that of group A(47.8%,P<0.05).The incidence of adverse reactions in group A(39.1%)was also significantly higher than that of group B(18.6%,P<0.05).The incidence of abdominal pain,abdominal distension,and abnormal liver function was significantly higher in group A than in group B(P<0.05 or P<0.01).The incidence of adverse reactions in the 8-12 cm,13-16 cm,and 17-20 cm subgroups treated with absolute ethanol was 15.4%,43.8%,and 81.8%,respectively(P<0.01),and the incidence in group c was significantly higher than that of groups a and b(P<0.05 or P <0.001).The incidence of abnormal liver function in the 8-12 cm,13-16 cm,and 17-20 cm subgroups treated with absolute ethanol was 11.5%,37.5%,and 81.8%,respectively(P<0.001),and the incidence in group c was significantly higher than that of groups a and b(P<0.05 or P<0.001).There were no significant difference in the incidence of adverse reactions or abnormal liver function between the three subgroups treated with lauromacrogol(P>0.05).Conclusion: The total effective rate of anhydrous alcohol and lauromacrogol in the treatment of large hepatic cysts is comparable,but lauromacrogol is associated with a higher cure rate and lower incidence of adverse reactions.