The Effects Of Muaid And Triamcinolone Acetonide Oral Ointment In The Treatment Of Erosive Oral Lichen Planus

Objective: To compare the short-term clinical efficacy of the treatment of erosive lichen planus with MuAid assist triamcinolone acetonide oral ointment and the treatment of erosive oral lichen planus with triamcinolone acetonide oral ointment alone.To investigate the role of MuAid in the treatment of erosive oral lichen planus with triamcinolone acetonide oral ointment,by comparing the changes of pain degree,the healing of erosive surface and the incidence of adverse reactions after treatment between the two groups.Methods:60 cases of erosive oral lichen planus(OLP)were collected from April 2018 to December 2018 in the Department of Oral Mucosal Disease,Stomatology Hospital of Hebei Medical University.All patients were diagnosed as erosive oral lichen planus according to medical history,clinical manifestations,pathology and ruled out the patients involved in exclusion criteria.Sixty patients with erosive oral lichen planus were randomly divided into two groups: group A(n = 30)and group B(n = 30).All the patients were examined by the same doctor,and the symptoms and oral lesions were recorded according to the same standard.Explained the patient's condition and Given patients general treatment,such as psychological guidance,oral health education,removal of local stimulus factors etc.Routine administration of group A and group B:Sodium bicarbonate tablets(A 3% concentration of sodium bicarbonate solution with cool boiled water)10 ml per day,3 times a day,gargle;Xipayi Guyin Ye,10 ml per day,3 times a day,gargle;Total Glucosides of White Paeony Capsules,0.6g per day,3 times a day.On this basis:Group A received triamcinolone acetonide oral ointment 3 times a day.Group B received triamcinolone acetonide oral ointment+ MuAid 3 times daily.Local medication method:Triamcinolone acetonide oral ointment is only used on the surface of oral lichen planus erosion.The best dosage is to cover all the erosive areas,and should not be rubbed repeatedly;The dosage of MuAid should cover all areas of triamcinolone acetonide ointment.If the lesion area is extensive,mouthwash can be used to make the gel cover the whole oral mucosa evenly;Do not gargle and eat at 1 hour after medication;Stop using triamcinolone acetonide oral ointment and MuAid after healing of erosive surface.At 1 week,2 weeks,4 weeks after treatment,the patients' subjective pain degree,area of erosion and adverse reactions were recorded by the same doctor according to the same criteria.The clinical symptoms and signs of the two groups were compared before treatment and 1 week,2 weeks and 4 weeks after treatment.The total effective rate of 4 weeks after treatment was used as the index to evaluate the curative effect,and the adverse reactions of the two groups were observed.Data analysis using SPSS21.0 statistical software.Results:1.General condition of patientsOne of 30 patients in Group A lost avisit.A total of 29 effective cases,average age(51.55 ±11.40)years,7 males and 22 females;30 patients in group B.2 patients missing visit,one patient faliure to return when 1week's follow-up,one patient surgically removed the lesions of erosison and hyperplasia during treatment and no more medication as ordered by the doctor.A total of 26 effective cases,average age(53.35 ±12.09)years,3 males and 23 females.There was no significant difference in general conditions between the two groups(P > 0.05),which was comparable.2.Comparison of pain degree between two groups before and after treatmentThere was no significant difference in the degree of pain between the two groups before the treatment(P = 0.313).The pain degree of the two groups was alleviated after the treatment.There was no significant difference in the degree of pain between the two groups 1 week after treatment(P < 0.129),but the degree of pain in group B was significantly lower than that in group A at 2 weeks and 4 weeks(P < 0.05).3.Comparison of lesion erosion area between two groups before and after treatmentBefore treatment,there was no significant difference in the area of erosion between the two groups(P = 0.344).The area of erosion in both groups decreased after treatment.There was no significant difference in the area of erosion between the two groups 1 week after treatment(P < 0.399).After 2 weeks and 4 weeks,the area of erosion in group B was significantly smaller than that in group A(P < 0.027,P < 0.009).4.Comparison of the total effective rate of 4 weeks after treatment between the two groupsFour weeks after treatment,29 patients in group A were effective in 8 cases,effective in 15 cases and ineffective in 6 cases in group B,26 cases in group B were effective in 16 cases and effective in 10 cases.The total effective rate of group B was significantly higher than that of group A(P < 0.024)4 weeks after treatment.5.Comparison of the incidence of adverse reactions between the two groups at 4 weeks after treatmentThe patients in both groups were treated for 4 weeks,in the group A,3 out of 29 patients had local burning painat the early stage of administration of the drug;2patients suffered from dry mouth and nausea after drug application.A case of local mucosal pigmentation,hyperplasia of tongue dorsal filamentous papillae,dark tongue coating,suspected fungal infection.No adverse reactions were observed in group B.After 4 weeks,the incidence of adverse reactions in group A was significantly higher than that in group B(P < 0.024).Conclusion:1.Triamcinolone acetonide oral ointment combined with local and systemic treatment of erosive oral lichen planus has a good clinical effect.2.MuAid assisted triamcinolone acetonide oral ointment can improve the clinical efficacy of erosive oral lichen planus.3.MuAid assisted triamcinolone acetonide oral ointment in the treatment of erosive oral lichen planus can reduce the incidence of adverse reactions in the treatment of erosive oral lichen planus treated with triamcinolone acetonide oral ointment alone.