Comparison Of The Clinical Efficacy Of Budesonide And Triamcinolone Acetonide In The Treatment Of Erosive Oral Lichen Planus

Objective It's designed to observate and compare the clinical efficacy,safety and convenience between a spray of budesonide and partial closure injection of triamcinolone acetonide,explore a more feasible way of glucocorticoid to treat erosive oral lichen planus,and provide clinical reference for the topical treatment of erosive oral lichen planus.Methods 70 Patients diagnosed with oral erosive lichen planus by clinical or pathological diagnosis,were randomly divided into treatment group 1 and treatment group 2, 35 cases in each according to treatment order which is divided into odd and even numbers.The treatment group 1 was sprayed budesonide onto localized lesions,and no gargling,eating,and swallowing in 1h after treatment,2 times a day, and 4 weeks as an observation period. The treatment group 2 was treated with triamcinolone acetonide 40 mg + 2% lidocaine 1ml,which were injected into the erosion of the mucosa base,each injection triamcinolone acetonide 20 mg,once a week, and 4 weeks as an observation period. Processing data by the SPSS19.0 professional statistical software package,compare two groups efficacy and adverse reactions and relapse after treatment by different modes of administration and different drugs.Result A topical spray of budesonide sprays and local injection of triamcinolone acetonide in the treatment of erosive oral lichen planus have significant clinical effects, erosion surface area decreases,the patients' degree of pain relief.The two groups were compared, the total efficiency of budesonide is 82.86%, the total efficiency of triamcinolone acetonide acetate is 80.00%, no significant difference(Z=-1.027,P>0.05). During the treatment of two groups, the adverse reactions of the budesonide group were found in 1 case, triamcinolone acetonide was found 2 cases of adverse reactions in the other group, P>0.05, no significant difference. After cured of two groups, with following up for 3 months, the rate of recurrence of the budesonide group was 10.00%; the triamcinolone acetonide group was13.33%, P>0.05, no significant difference.Comparison of patient acceptance between spray topical corticosteroids and local corticosteroids injection,acceptance is divided into four sections(Z =-3.115, P <0.05), the difference was statistically significant.71.43% of patients receiving topical use spray in the budesonide group, 45.71% of patients received local injection in the triamcinolone acetonide group, the difference was statistically significant( ? 2 = 4.768, P <0.05).Conclusion 1.Both budesonide and triamcinolone acetonide in the treatment of erosive oral lichen planus can obtain the better curative effect. 2. Topical sprays with budesonide can be used as a treatment of erosive oral lichen planus alternative to the topical injection of triamcinolone acetonide.