Effects Of Epidural Anesthesia For Labor Analgesia On The Level Of Leptin And Cortisol In Umbilical Cord Blood

Objective:To evaluate the effect of epidural anesthesia for labor analgesia on the level of leptin and cortisol(COR)in umbilical cord blood.Methods:Sixty primiparas,aged 22~33 years,ASA I or II,with a single fetus at full term lying in normal headdown position were elected,the primiparas who met the standard voluntary epidural analgesia were assigned to observation group,the primiparas who voluntarily gave up labor analgesia were divided into control group,(n=30 each).Observation group:When the cervical dilation was opened to 3cm,the epidural puncture was performed in the L2-3 intervertebral space.An epidural catheter was placed at the head end,and the experimental dose of 1% lidocaine was injected,follow by an observation for3 to 5 minutes to excluding the catheter from the vascular or subarachnoid space,and then8-12 ml of the mixture of 0.1% ropivacaine with 0.25Ug/ml sufentanil was injected as the first dose to obtain a satisfactory effect followed by PCA pump.The background infusion rate is 8-12ml/h,PCA volume 3-5ml,locking time 30 minutes,the maximum amount of20 ml per hour,fetal placenta delivered,suture wounds completed followed by the witndrawal of the tube:Control group:according to the conventional natural delivery procedures.The leptin and cortisol(COR)concentrations in the umbilical arterial blood was measured by the Elisa method.Results:The VAS score in observation group after labor analgesia was significantly lower than than that in control group(P < 0.05).There were no significant difference in NABA score,umbilical venous blood leptin and COR ratio between the two groups.Conclusion Epidural labor analgesia has no effect on the level of leptin and cortisol(COR)in cord blood.Conclusion:The analgesia has no effect of epidural labor analgesia is exact.It is a safe and effective method of labor analgesia.