Cognitive Function Of Bipolar Depression Patients And Its Correlation With Metabolomics

Objective:1.To clarify the characteristics of cognitive function in patients with bipolar depression;2.To explore metabolic biomarkers of cognitive impairment in patients with bipolar depression.Methods:Fifty-six patients with bipolar depression and 66 normal controls were selected from the outpatient and ward of Mental Health Department of Shanxi Da Yi Hospital.Repeatable Battery for the Assessment of Neuropsychological Status and Stroop Color-Word Test were used to evaluate the cognitive function of the two groups and analyze the cognitive impairment of the patients.Sixteen patients with bipolar depression were divided into cognitive impairment group and non-cognitive impairment group by the total score of cognitive impairment compared with the normal group.Fasting venous blood samples were collected,supernatant was extracted by centrifugation and detected by magnetic resonance technology.Typical 1H NMR maps were obtained,and the maps were processed and analyzed to find the corresponding biomarkers.Results:1.Comparison of cognitive function between bipolar depression patients and normal subjects:The results of RBANS test showed that the scores of immediate memory,vocabulary learning,story retelling,speech function,language fluency,attention,coding test,delayed memory,vocabulary re-recognition,recall,story and total table of bipolar depression patients were lower than those of the normal group,and the difference was statistically significant(p < 0.05).Stroop test results showed that the number of monochrome errors,bichrome errors,single-word time,monochrome time,double-word time and double-color time in patientswith bipolar depression were significantly higher than those in the control group(p < 0.05).2.Multiple linear regression analysis of demographic data on cognitive function:Educational level had statistical significance in immediate memory,vocabulary learning,story retelling,visual breadth,line positioning,speech function,picture naming,attention,coding test,recall,story,total score,word usage time,monochrome usage time,bichrome error number dimension(p < 0.05);age had statistical significance in vocabulary learning,story retelling,graphic copying,coding test,story,picture.The dimension of shape,monochrome time,double-character time and double-color time had statistical significance(p < 0.05).3.Analysis of the correlation between clinical symptoms and cognition:Among the factors of HAMD,blockade was negatively correlated with visual breadth,graphic copying,speech function,picture naming,semantic fluency,attention,coding test,story and total score(r < 0,p < 0.05);despair was negatively correlated with visual breadth,graphic copying,total score and total score of test(r < 0,p < 0.05).There was a significant negative correlation between graphic copying(r < 0,p < 0.05).There was a significant positive correlation between somatic anxiety and the number of double-word errors in HAMA scale(r > 0,p < 0.05).4.Metabolomic analysis of cognitive function in patients with bipolar depression:There were six different metabolites in the plasma samples of the two groups:isoleucine,leucine,valine,N-acetyl glycoprotein,glutamic acid and choline.Conclusion:1.Bipolar depression patients generally have cognitive impairment,which is mainly manifested in memory,attention and execution.2.Cognitive function is mainly affected by many factors.This study is mainly reflected in the education level and age.3.There is a certain relationship between clinical symptoms and cognitive function of bipolar depression,that is,the more serious the depression is,the greater the cognitive impairment is.4.Metabolic biomarkers of cognitive impairment in bipolar depression may beisoleucine,leucine,valine,N-acetyl glycoprotein,glutamic acid and choline.