Observation On The Curative Effect Of Piweikang Granule In The Treatment Of Infective Diarrhea Caused By Rotavirus In Children

ObjectiveThe clinical effect of spleen Weikang granule on infantile rotavirus infectious diarrhea was studied by clinical observation.The clinical characteristics of spleen Weikang granule on infantile rotavirus diarrhea and the modern medical effect of spleen Weikang granule on children with rotavirus diarrhoea were compared and analyzed,and the clinical effect of spleen Weikang granule on infantile rotavirus infectious diarrhea was analyzed.To provide a new drug reference for the treatment of infantile rotavirus infectious diarrhea.MethodsIn this study,68 children with acute diarrhea caused by rotavirus infection were divided into control group（n=34）and experimental group（n=34）.The control group was treated with oral rehydration salt and montmorillonite powder,while the treatment group was treated with Piweikang granule and oral rehydration salt.To observe the total effective rate,the time of stopping diarrhea,the quantitative integral of TCM symptom,the level of IL-6 serum concentration,and to evaluate objectively the clinical curative effect and action characteristics of Piweikang granule in treating infective diarrhea of infective rotavirus in children.Results1、After clinical control treatment,the total effective rate was 94.12 in the treatment group and 67.67 in the control group.After Mann-Whitney U test,there was a significant difference between the two groups（Mann-Whitney U381PU 0.01<0.05）.Fisher X2 test showed that the total effective rate of the treatment group was better than that of the control group,and the difference was statistically significant（X2+8.867 PO.031<0.05）.2、Before the treatment,the total score of the clinical syndromes in the treatment group and the control group were compared.By the homogeneity test of variance,the variance of the two groups was equal(F_0.27P_0.64>0.05),and the independent sample t test was used to compare the total scores of the clinical syndromes of the treatment group and the control group.There was no significant difference in the scores of TCM clinical symptoms in the treatment group（t=0.606,P<0.547>0.05）,which was comparable.After treatment,the scores of TCM clinical syndromes in the treatment group were significantly different by homogeneity test of variance（FV 2.49）（P<0.11>0.05）and independent sample t test（t=2.05）.,PO.04<0.05).There were significant differences in the scores of TCM syndromes before and after treatment in the treatment group and in the control group before and after treatment(t_19.00P_0.00<0.05),while in the control group there was a significant difference(t_14.11P₀P_0.00<0.05).It can be seen that the two groups of treatment can improve the syndrome score of children.The difference before and after treatment was found to be uneven by the homogeneity test of variance（FV 4.22/P<0.05）.By independent sample t,there was a significant difference in syndrome score between the treatment group and the control group（t=2.38%）（t=2.38%,P<0.05）,and a significant difference was found between the two groups（t=2.3805,P<0.05）.2.02<0.05),the treatment group is superior to the control group in improving TCM symptoms.3、In the time of stopping diarrhea,the time of stopping diarrhea in the treatment group and the control group was examined by homogeneity test of variance,the variance was equal（FN 0.38%P<0.57）,and the time of stopping diarrhea in the treatment group was significantly different from that in the control group（t=-3.13）.PO.03<0.05),which indicated that the treatment group had a significant advantage over the control group in the time of stopping diarrhea.There was no significant difference in serum interleukin-6 levels between the two groups before treatment（t=0.21,P=0.84）,which was comparable.After treatment,the two groups were tested for homogeneity of variance.By independent sample t test,there was a significant difference in serum interleukin-6 between the treatment group and the control group（t-4.4,P<0.05）,and there was no significant difference between the treatment group and the control group（t=0.74,t=0.74）.It suggested that the treatment group had obvious advantages over the control group in reducing serum interleukin-6 in rotavirus infective diarrhc a.Mann-Whitney U test:compared with the control group,there was no significant difference in the scores of appetite symptoms before treatment in the treatment group（Mann-Whitney U=571,P=0.923>0.05）.After one course of treatment,the scores of appetite symptom showed significant difference（Mann-Whitney U=425,P<0.028）,which indicated that the treatment group was superior to the control group in improving the appetite of the children.Mann-Whitney U test:compared with the control group,there was no significant difference in the scores of appetite symptoms before treatment in the treatment group（Mann-Whitney U=571,P=0.923>0.05）.After one course of treatment,the scores of appetite symptom showed significant difference（Mann-Whitney U=425,P<0.028）,which indicated that the treatment group was superior to the control group in improving the appetite of the children.4、After one course of treatment,stool rotavirus antigen was tested again,indicating that 25 children in the treatment group turned negative in antigen detection,17 in the control group turned negative,and Pearson chi-square test（X2C3.985Pn.046<0.05）.The results showed that the difference of sample f’requency between the two groups was statistically signif’icant.It can be concluded that the curative effect of spleen stomach Kangfang granule in treating rotavirus infective diarrhea is higher than that in the control group.Conclusion1.In treating infective diarrhea of rotavirus in children,the prescripticln of spleen and stomach can improve the clinical symptom score of TCM,shorten the time of stopping diarrhea,regulate the body as a whole and promote the recovery.2.The treatment of infective diarrhea caused by rotavirus in children with spleen and stomach prescription showed that it promoted the seroconversion of rotavirus antigen and affected the expression of inflammatory factor IL-6 in serum.