Thromboelastography Evaluates Coagulation Status In Patients With Phlegm And Blood Stasis With Coronary Heart Disease Complicated With Obstructive Sleep Apnea Syndrome

ObjectiveUsing the method of cross-sectional investigation,the coagulation status of patients with sputum stasis and obstructive sleep apnea syndrome(OSAHS)was investigated by TEG to find out the effect of OSAHS on coagulation function in patients with phlegm and blood stasis and coronary heart disease,and to provide reference for the diagnosis and treatment of such patients in clinic.MethodsThe coronary heart disease was hospitalized in the heart of the University City Hospital of Guangdong Provincial Hospital between January 2019 and April 2018,and all patients were perfected during hospitalization,such as sleep Respiratory monitoring(PSG),TEG and routine physical and chemical examination,and four diagnostic information collection in TCM.Among them,97 patients who met the inclusion criteria,according to the diagnostic criteria of the sleep apnea group of the Chinese Medical Association Respiratory Pathology Branch,according to the PSG results were divided into simple coronary heart disease Group(control group,n=27 people)and coronary heart disease combined with OSAHS group,while coronary heart disease combined with OSAHS group and then judged its severity according to PSG results,According to the Apnea Hypopnea index(AHI),it was divided into mild group(N=34),Moderate group(N=22)and severe group(N=14).The 97 patients were collected from PSG,TEG,routine physical and chemical examination,TCM four diagnosis information and other related clinical data.Use Spss25.0 for statistical analysis.Compare the changes of TEG levels between groups.Results1.The differences in TEG indicators in such patients were statistically significant among the groups,and the severity of the indicators was positively correlated with the severity of the OSAHS(P>0.05).2.TEG indicators are mainly related to HB,PLT,RBC,FIB,APTT and AHI indices,while HB,APTT,PLT,FIB and RBC are the main independent predictors of TEG indicators.Conclusion.1.OSAHS will aggravate the hypercoagulability of patients with coronary heart disease,and the severity is positively correlated with the severity of OSAHS.2.TEG has a good correlation with clinical routine coagulation index and severity index of OSAHS patients,TEG may be a better choice for monitoring hypercoagulability in patients with coronary heart disease and OSAHS,but more evidence is needed to support it.