A Study On Correlation Between Coronary Heart Disease And Obstructive Sleep Apnea Syndrome

BackgroundClinical-based studies suggested that obstructive sleep apnea syndrome (OSAS)is an independent risk factor for coronary heart disease(CHD),but the specific mechanism have not been proving completely yet. The purpose of the study was to investigate the blood fat,uric acid,glucose metabolism of the OSAS complicating CHD patient,which might help to explain mechanism for obstructive sleep apnea syndrome to led to coronary heart disease,and through nasal continuous positive air pressure (n-CPAP)may improving the clinical symptom and elevate quality of life,to provide evidence for coronary heart disease second-level prevention. Methods 1.Following polysomnographic examination 51 adult male habitual snorers were divided into 2 groups: 26 simple OSAS; 25 with OSAS and CHD. There was no significant difference in age and body mass index (BMI) among the 2 groups.2.we compared apnea-hypopnea index,systolic blood pressure,diastolic blood pressur, glucose,non–high-density lipoprotein cholesterol,Total cholesterol,Triglycerid , Low density lipoprotein cholesterol , uric acid,total cholesterol/ high-density lipoprotein cholesterol,Apo-a,Apo-b between the two groups. The 13 people whom from the two groups,we compared their apnea-hypopnea index,minimal pulse oximetric saturation before and after one month nasal continuous positive air pressure therapy.3.comparing the morbidity rate of the two groups for hypertensive disease,Diabetes Mellitus and stroke.4.All data were recorded by computer and SPSS 17.0 for windows software, was used for statistic analysis including two independent sampler t,two independent sampler Wilcoxon rank sum test,Paired-Samples T Test,chi square test ,p<0.05 was considered statistically significant.Results There was no diffrernce about the SBP,DBP,LDL-c,TG,Glu,AHI ,LDL-c,HDL-c, TC,Apo-a,Apo-b ,MinSpO2between the two groups,but the non-HDL-c,UA,TC/HDL-c all higher in with OSAS and CHD complic patients at baseline. After one month's follow-up, there is significant difference for the AHIandMinSpO2.The 13 patient symptom such as chest distress ,chest pain, daytime lethargic ,snore relieved, and living standard elevated.ConclusionsPatients with OSAS and CHD exist obviously metabolic disorder of blood fat and uric acid,this maybe one of mechanisms to promote the happening and development of CHD; the detection of non-high density lipoprotein,uric acid,TC/HDL-c index maybe as a prediction index for OSAS with CHD patient. Nasal continuous positive airway pressur therapy is a effective therapeutic tool,The Second-level prevention of CHD maybe based on that.