The Analysis Of Relationship Between Coronary Heart Disease And Obstructive Sleep Apnea Hypopnea Syndrome

Objective:Analysis the relation between coronary heart disease(CHD) and obstructive sleep apnea hypopnea syndrome(OSAHS) in patients with clinical data, to explore the clinical relevance between the two diseases. It is intended to provide the some clues for the treatment of combined CHD patients with OSAHS. Methods:Selection in January 2014- September 2014 at the Tianjin people’s hospital of cardiovascular internal medicine(the CAG) confirmed by coronary angiography examination for coronary heart disease(CHD) and respiratory sleep monitoring(PSG) of patients as the research object, a detailed record of the patient’s medical history data, clinical laboratory tests, and imaging findings. Coronary angiography by high qualification interventional physicians examination, and calculate the SYNTAX score and CTFC counting(corrected TIMI flow frames). The study ultimately selected 80 patients between the ages of 37-70 years, mean age 56.8 ± 7.1 years, 49 men and 31 females. Based on the apnea-hypopnea index(AHI) were divided into a control group and the experimental group, the experimental group including mild OSAHS group, moderate OSAHS group, and severe OSAHS group. Analysis of the clinical laboratory results and imaging findings, and compare the differences between the various groups of patients. Results:(1) The basic situation of patients in each group and history,compared to P> 0.05, no statistical difference, comparable.(2) Laboratory test results for each group of patients suggest that fasting blood glucose was higher than that of mild to moderate OSAHS OSAHS group(P = 0.017), high-sensitivity C-reactive protein(hs-CRP) in severe OSAHS group than mild OSAHS group(P = 0.020), the difference was statistically significant.(3) Patients with left ventricular ejection fraction in each group(LVEF) Analysis, P> 0.05, the difference was not statistically significant.(4) Patients in each group laboratory and SYNTAX score results showed that patients in each group ICAM-1, IL-8 comparison, P> 0.05, the difference was not statistically significant. SYNTAX score patients in each group, P values were less than 0.05, the difference was statistically significant. AHI and coronary SYNTAX score was no significant correlation(P = 0.084).(5) Slow flow of patients in each group, the difference was statistically significant(P <0.05)(6)AHI patients in each group predicted area under the ROC curve of 0.758 slow flow, sensitivity and specificity of 70% and 18%, the area under the ROC curve hs-CRP predict slow flow of 0.600, sensitivity and specificity of 65% and 43% of the area under the blood glucose predicted slow flow of ROC curve 0.629, the sensitivity and specificity of 75% and 43%.(7)Each group of coronary artery cTFC significantly(P <0.05) Conclusions:1. Coronary heart disease combined OSAHS patients gluco lipid metabolic disorders, overweight. Them in the development of coronary heart disease and the occurrence of OSAHS, has the important influence.2. Coronary heart disease with OSAHS patients had chronic inflammatory process, With the increment of OSAHS illness degree, hs – CRP increased.3. AHI and coronary SYNTAX score was no significant correlation, but each group of patients in the SYNTAX score difference was statistically significant, suggesting that OSAHS have a certain influence on the development of coronary heart disease.4. AHI can predict slow blood flow to a certain extent.