| Objective:to understand the distribution differences of TCM syndromes of hypertension and explore the clinical differences between different syndromes in renin aldosterone and blood pressure variability,so as to better guide clinical prevention and treatment.Methods: the renin aldosterone test and 24 h dynamic blood pressure monitoring were performed on 467 hypertensive patients,and the general data were collected to fill in the TCM syndrome element questionnaire.Results:(1)general data analysis.467 patients with hypertension were included in the study,including 377 cases of single syndrome element and 90 cases of mixed syndrome element.The frequency analysis of 377 patients with single syndrome element hypertension showed that the frequency distribution of solid syndrome element was: phlegm syndrome,>Yang,hyperactivity,> qi,stagnation,> blood stasis.Among them,phlegm syndrome was the most(92 cases of phlegm syndrome,24.40%),indicating that the majority of solid syndromes of hypertension patients with single syndrome were phlegm syndrome.The frequency distribution of deficiency syndromes is: Yin deficiency,>,qi deficiency,>,blood deficiency,>,Yang deficiency.Among them,Yin deficiency was the most common(92 cases,13.00%),indicating that Yin deficiency was the dominant syndrome in patients with single syndrome element hypertension.The frequency of qi stagnation and phlegm obstruction(15 cases of phlegm syndrome/qi stagnation,16.67%)was higher in the solid syndrome(15 cases of phlegm syndrome/qi stagnation,16.67%).In the deficiency syndrome,the frequency of qi and blood deficiency was higher(13 cases,14.44%).The frequency of Yin deficiency and Yang hyperactivity was higher in the deficiency positivist elements(12 cases,13.33%).In this study,467 patients with hypertension were aged between 30 and 65 years old.The age distribution of single syndrome elements was significantly different,p<0.05,and multiplecomparisons showed that the age difference between qi deficiency,qi stagnation and Yang activity was significant.P > 0.05,no statistical significance,no significant difference was found in the age group of patients with hypertension complicated by heterozygotes.There were 294 male patients(62.90%)and 173 female patients(37.10%),with a male to female ratio of 1.7:1.The chi-square test showed a significant difference in the gender distribution of single syndrome elements,p<0.05,in which phlegm syndrome,males accounted for a high proportion,accounting for 90.2%.The proportion of blood deficiency and Yin deficiency in females was higher than that in males.According to the analysis of the gender distribution of the multiple syndromes,the chi-square test showed a significant difference(p<0.05),among which the male accounted for a relatively high proportion.Patients with hypertension were divided into grade I,II and III,with 22 patients(4.71%)with grade I hypertension,127 patients(27.20%)with grade II hypertension,and 318 patients(68.09%)with grade III hypertension.The overall comparison of renin in each single syndrome showed differences,and multiple comparisons showed that there was a significant difference between blood deficiency and phlegm syndrome,P < 0.05,The difference between blood deficiency and phlegm syndrome is obvious.The overall comparison of aldosterone in hypertension patients with single syndrome element(P > 0.05)showed no statistical significance and no significant difference.Overall comparison of renin and aldosterone in patients with concurrent syndrome hypertension showed no statistically significant difference(P > 0.05).(2)There were overall differences in the blood pressure variability among the single syndromes of 24-hour systolic blood pressure,daytime systolic blood pressure and nighttime systolic blood pressure,P <0.05,which was statistically significant.In addition,multiple comparisons showed that the differences between qi deficiency and blood deficiency,Yang deficiency and phlegm in different diastolic blood pressure syndromes within 24 hours were obvious,and the differences between qi stagnation and phlegm syndrome,blood stasis,Yin deficiency,blood deficiency and Yang deficiency were obvious,and the differences between phlegm syndrome and Yang hyperactivity were obvious.The difference of qi stagnation,phlegm syndrome and blood deficiency in different systolic blood pressure syndromes is obvious.The difference of phlegm syndrome,qi deficiency,qi stagnation and Yang activity in different syndrome elements of nocturnal systolic blood pressure was obvious.The blood pressure variability of 24-hour systolic blood pressure,daytime systolic blood pressure and nighttime systolic blood pressure was compared as a wholeamong the patients with hypertension complicated with heterozygous syndrome,P>0.05 showed no statistical significance and no significant difference.There was an overall difference in the diastolic blood pressure and nocturnal diastolic blood pressure variability between the single syndrome elements,P<0.05,which was statistically significant,and the multiple comparisons showed that: the differences of qi deficiency,Yang deficiency and phlegm in the different syndrome elements of 24-hour diastolic blood pressure were obvious.The difference between qi deficiency and phlegm in different diastolic blood pressure syndromes at night was obvious.Overall comparison of diastolic blood pressure variation coefficient between single syndrome elements in the daytime showed no statistical significance or significant difference in P>0.05.There was an overall difference between the patients with 24-hour diastolic blood pressure variability and heterozygous syndrome elements(P<0.05,with statistical significance),The overall comparison of blood pressure variability between daytime systolic blood pressure and nighttime systolic blood pressure in patients with concurrent syndrome hypertension(P>0.05)showed no statistical significance and no significant difference.Conclusion:(1)467 patients with hypertension were included in the study,including 377 patients with single syndrome element and 90 patients with mixed syndrome element.Frequency analysis of 377 patients with single syndrome element hypertension showed that the frequency distribution of different syndrome elements was different.The frequency distribution of different syndromes was different in 90 patients with hypertension.(2)there was a significant difference in the age distribution among the single syndrome elements,and there was no significant difference in the overall comparison of the age among the patients with concurrent syndrome elements hypertension.There were significant differences in the gender distribution of single syndromes and the gender distribution of heterozygous syndromes.(3)the overall comparison of renin among single syndrome elements showed differences,while the overall comparison of aldosterone among hypertension patients with single syndrome elements showed no significant differences.There was no significant difference between renin and aldosterone in the whole group.(4)there was an overall difference in the blood pressure variability of 24-hour systolic blood pressure,daytime systolic blood pressure and nighttime systolic blood pressure among the single factors;The blood pressure variability of 24-hour systolic blood pressure,daytime systolic blood pressure and nighttime systolic blood pressure was compared as a whole among the patients with hypertension complicated by miscellaneoussyndromes,and there was no significant difference.There was an overall difference between the diastolic blood pressure variation at 24 hours and diastolic blood pressure variation at night.There was no significant difference in diastolic blood pressure variation coefficient between single syndrome elements.There was an overall difference between the patients with 24-hour diastolic blood pressure variability and heterozygote hypertension.There was no significant difference in the variability of systolic blood pressure during the day and at night between the patients with hypertension complicated by heterozygins. |
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