Sanziliujun Tang Combined With NP Regimen On The Clinical Efficacy Of ? Non-Small Cell Lung Cancer

Objective:The incidence and mortality of lung cancer in the world and China account for a high proportion of malignant tumors,the vast majority of lung cancer is in the middle and late stage,there is no effective treatment of modern medicine,and the treatment of traditional Chinese medicine has its obvious advantages.We applied the principle of"one support,three guarantees"to lung cancer in clinical practice,and received good clinical efficacy.Therefore,we set up this subject,in order to explore for lung cancer patients in reducing their pain,improving the quality of life,and lay a foundation for the development of new drugs.Methods:According to the principle of randomized control of clinical trials,68cases of Patients with adenocarcinoma or squamous cell carcinoma or adenosquamous carcinoma in stage IV non-small cell lung cancer(NSCLC)who were clinically diagnosed as spleen-deficient and Phlegm-obstructing type of TCM syndrome differentiation were randomly divided into two groups:the control group(n=32)and the treatment group(n=32).In terms of treatment,the control group:NP regimen:vinorelbine(NVP)25mg/m~2 intravenous infusion,the first day and the eighth day;Cisplatin(DDP)75mg/m~2 intravenous infusion,the first day,or total in three days;21days is a cycle,4 cycles.The experimental group was treated with sanziliujun decoction on the basis of the control grouP,One dose a day,morning and evening Points take,21 days is a cycle,4 cycles.Firstly,blood routine(WBC,PLT,HB),ALT,Scr,and quality of life(card scale)were examined and recorded before and after treatment in all clinical patients.Secondly,TCM syndrome Points were compared before and after treatment.All data were analyzed by SPSS.21.0 statistical software.Patients with drug allergy or intolerance to chemotherapy were excluded from the study.Result:1.Before treatment,general data(age,gender)of TCM syndrome score and KPS score between the sanzi liujun decoction adding group and the control group showed no statistical difference(P<0.05).2.TCM syndrome points:Before treatment,the TCM symptom scale score of the two groups was P>0.05,indicating that there was no statistical difference between the two groups,and the two groups were comparable.P<0.05 was compared between the two groups before and after treatment,indicating that both drugs could improve symptoms.After treatment,P<0.05 was significantly different between the two groups,and the effect of the observation group was much better than that of the control group.There were 8 and 20 cases in the sanzi liujun decoction group.In the control group,there were 2 cases and 12 cases respectively.After test,P<0.05,there was a statistical difference between the two groups,the effect of sanzi liujun decoction was better tha n the control group.3.Quality of life(KPS score)There was no significant difference in KPS scores between the two groups before treatment,which was comparable.Before and after treatment,sanzi liujun decoction group P<0.05;Control group P>0.05.After treatment,P<0.05 was counted in the two groups,and there was a statistical difference between the two groups.The KPS score in the sanzi liujun decoction group was increased in16 cases and stabilized in 11 cases.In the control group,there were 6 cases with increased KPS score and 7 cases with stable KPS score.After test,P<0.05,there was a statistical difference between the two groups,the effect of sanzi liujun decoction was better than the control group.4.Toxic and side effects after chemotherapy:Both groups showed decreased white blood cell count,decreased hemoglobin concentration,decreased platelet count,increased alanine transferase,elevated serum creatinine,constipation,nausea and vomiting and other adverse reactions,but the experimental group showed less adverse reactions of degree III and degree IV than the control group,and symptomatic treatment could alleviate them.There were significant differences in the incidence of leukocyte count,hemoglobin concentration,platelet count,constipa tion,nausea and vomiting between the two groups(P<0.05),but no significant differences in the incidence of alanine transferase and serum creatinine(P>0.05).Conclusion:Sanziliujun decoction combined with NP regimen in the treatment of stage IV non-small cell lung cancer(NSCLC)with spleen-deficient Phlegm obstructing can improve the main symptoms,improve the quality of life and reduce the complications.The effect of sanzi liujun decoction on stage IV non-small cell lung cancer(NSCLC)is better than that of chemotherapy alone.As for the side effects of other chemotherapy treatments,it has the effect of significantly reducing side effects and high safety.