Clinical Observation Of Dima Grnule On Ulcerative Colitis Of Spleen Deficiency And Damp-heat Type And Its Effect On Serum Inflammatory Factor

1.Objective:To observe the changes of single TCM syndrome points,symptoms total integral,TCM comprehensive curative effect,disease activity index,endoscopic score and serum inflammatory factor level of Dima granule after the treatment of spleen deficiency and damp-heat UC,to evaluate its clinical efficacy and safety,and to explore the mechanism of its anti-UC.2.Methods:From December 2017 to October 2018,60 patients with chronic ulcerative colitis(active,mild to moderate)clinically diagnosed with spleen deficiency and damp-heat syndrome differentiation in traditional Chinese medicine were selected from the department of spleen and stomach diseases and outpatient department of Anhui Provincial Hospital of Traditional Chinese Medicine.The patients were randomly divided into the TCM group and the control group,with 30 cases in both groups.The traditional Chinese medicine group was treated with Dima granule combined with mesalazine and the control group with mesalazine.Before and after treatment,the changes in comprehensive efficacy,single TCM syndrome score and total syndrome score,disease activity index and serum inflammatory index were compared between the two groups.3.Results: 3.1 Influence of Dima granules on single and total points of TCM syndromes in UC patients:After treatment,both groups could reduce the total score of TCM syndromes and improve the clinical symptoms of UC,and the total score of TCM syndromes in the TCM group was significantly lower than that in the control group,the difference was significant(P<0.05).After the treatment,single TCM syndrome points of abdominal pain,diarrhea,mucous pus and blood stool,fatigue and fatigue,poor appetite and tenesmus in the TCM group were all lower than those in the control group,and the difference was statistically significant(P<0.05).That of the control group showed no statistical significance(P>0.05).3.2 Comprehensive efficacy of TCM:At the end of the 4-week treatment cycle,the effective rate of the TCM group was 93.30%,the effective rate of the control group was 70%,with significant difference between two groups(P<0.05).3.3 Efects of Dima granules on Mayo scores in UC patients:At the end of the course of treatment,both groups of Mayo scores were improved compared with the previous group,with significant difference between two groups(P<0.05).Intergroup comparison,the degree of reduction of Mayo score in the TCM group was more significant,with significant difference between two groups(P<0.05).indicating that the improvement of Mayo score in the TCM group was better than that in the control group.3.4 Effect of Dima granule on serum inflammatory cytokines in UC patients:After treatment,serum CRP,IL-8 and TNF-? were significantly decreased in both groups.Compared with the two groups,serum inflammatory cytokines were significantly decreased in the traditional Chinese medicine group,with significant difference between two groups(P<0.05).3.5 Drug safety monitoring:During the monitoring period,there were no adverse reactions in the TCM group,and 3 patients in the control group had mild nausea and vomiting gastrointestinal symptoms without special treatment.4.Conclusion: 4.1 Dima granule combined with mesalazine can improve the efficacy of TCM syndrome in patients with spleen deficiency damp-heat UC and strengthen the therapeutic effect.4.2 Dima granules combined with mesalazine may reduce the expression levels of CRP,IL-8 and TNF-?,so as to achieve the anti-inflammatory effect in UC patients.4.3 Dima granules combined with mesalazine can reduce the disease activity index,promote disease to alleviate 4.4 Combination of Dima granule and mesalazine for the treatment of UC has no reports of adverse reactions and higher safety.